RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - METABOLISMO LOCALE ED ESPRESSIONE GENICA: NUOVE PROSPETTIVE IN CHIRURGIA
• 2 - PEROSSIDAZIONE LIPIDICA, ATTIVAZIONE PIASTRINICA ED INFIAMMAZIONE ASSOCIATI A RIDOTTI LIVELLI DI LIPOPROTEINE AD ALTA DENSITA' (HDL)
• 3 - Ruolo patogenetico del Brain-derived neurotrophic factor (BDNF) nell'eziologia delle patologie neurodegenerative: dai modelli animali allo studio nell'uomo.
• 4 - Studio degli effetti genomici dell'aldosterone in modelli cellulari ed in vivo.
• 5 - Ruolo delle adipochine, citochine infiammatorie e linfociti T regolatori nel determinismo dell’aterosclerosi accelerata e della sindrome metabolica in corso di lupus eritematoso sistemico.
• 6 - Determinanti genetici e molecolari del ruolo della COX-2 nell'aterotrombosi.
• 7 - Danno cardio-vascolare precoce in bambini ed adolescenti obesi :la identificazione di markers di rischio metabolici e/o genetici rende possibile la diagnosi precoce e può migliorare la qualità della vita futura.
• 8 - Sistema nervoso centrale e periferico ed infezione da virus dell'epatite C: manifestazioni clinico-patologiche, potenziali fattori favorenti la neuro-invasione, meccanismi del danno neurale.
• 9 - Ruolo dei geni protettivi endogeni nella prevenzione del danno vascolare: studio in un modello preclinico e studio clinico in una popolazione a rischio.
• 10 - Iperlipidemia, Aterosclerosi e Insufficienza Renale

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • NEUROLOGIA

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lazio

Bibliografia

1.Dutka, A.J., P.M. Kochanek, and J.M. Hallenbeck, Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. Stroke, 1989. 20(3): p. 390-5.
2.Connolly, E.S., Jr., et al., Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion. Role of neutrophil adhesion in the pathogenesis of stroke. J Clin Invest, 1996. 97(1): p. 209-16.
3.Loddick, S.A. and N.J. Rothwell, Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab, 1996. 16(5): p. 932-40.
4.Iadecola, C., et al., The transcription factor interferon reg0ulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury. J Exp Med, 1999. 189(4): p. 719-27.
5.Takeda, H., et al., Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats. Stroke, 2002. 33(9): p. 2156-63.
6.Storini, C., et al., C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation. Neurobiol Dis, 2005. 19(1-2): p. 10-7.
7.De Simoni, M.G., et al., Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia. J Cereb Blood Flow Metab, 2003. 23(2): p. 232-9.
8.Castillo, J., et al., The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke. Ann Neurol, 2003. 54(6): p. 811-9.
9.Hallenbeck, J.M., The many faces of tumor necrosis factor in stroke. Nat Med, 2002. 8(12): p. 1363-8.
10.Kuo, H.K., et al., Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis. Lancet Neurol, 2005. 4(6): p. 371-80.
11.Ferrarese, C., et al., Increased cytokine release from peripheral blood cells after acute stroke. J Cereb Blood Flow Metab, 1999. 19(9): p. 1004-9.
12.Smits, B.W., et al., Stress susceptibility as a determinant of the response to adrenergic stimuli in mesenteric resistance arteries of the rat. J Cardiovasc Pharmacol, 2002. 40(5): p. 678-83.
13.Perry, V.H., T.A. Newman, and C. Cunningham, The impact of systemic infection on the progression of neurodegenerative disease. Nat Rev Neurosci, 2003. 4(2): p. 103-12.
14.Combrinck, M.I., V.H. Perry, and C. Cunningham, Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience, 2002. 112(1): p. 7-11.
15.Pereira, H.A., X. Ruan, and P. Kumar, Activation of microglia: a neuroinflammatory role for CAP37. Glia, 2003. 41(1): p. 64-72.
16.Castillo, J. and I. Rodriguez, Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc Dis, 2004. 17 Suppl 1: p. 7-18.
17.Emsley, H.C., et al., An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. J Neuroimmunol, 2003. 139(1-2): p. 93-101.
18.Kleindorfer, D., et al., Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke, 2005. 36(4): p. 720-3.
19.Weih, M., et al., Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke, 1999. 30(9): p. 1851-4.
20.Moncayo, J., et al., Do transient ischemic attacks have a neuroprotective effect? Neurology, 2000. 54(11): p. 2089-94.
21.Schaller, B., Ischemic preconditioning as induction of ischemic tolerance after transient ischemic attacks in human brain: its clinical relevance. Neurosci Lett, 2005. 377(3): p. 206-11.
22.Kariko, K., D. Weissman, and F.A. Welsh, Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab, 2004. 24(11): p. 1288-304.
23.Taguchi, A., et al., Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation, 2004. 109(24): p. 2972-5.
24.Werner, N., et al., Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med, 2005. 353(10): p. 999-1007.
25.Nadareishvili, Z.G., et al., Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death. Neurology, 2004. 63(8): p. 1446-51.
26.Latini, R., et al., Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation, 2004. 110(16): p. 2349-54.
27.Wunderlich, M.T., et al., Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. Stroke, 1999. 30(6): p. 1190-5.
28.Foerch, C., et al., Serum S100B predicts a malignant course of infarction in patients with acute middle cerebral artery occlusion. Stroke, 2004. 35(9): p. 2160-4.
29.Foerch, C., et al., Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction. Arch Neurol, 2005. 62(7): p. 1130-4.
30.van Exel, E., et al., Inflammation and stroke: the Leiden 85-Plus Study. Stroke, 2002. 33(4): p. 1135-8.
31.Winbeck, K., et al., Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke, 2002. 33(10): p. 2459-64.
32.Di Napoli, M., et al., Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke, 2005. 36(6): p. 1316-29.
33.Smith, C.J., et al., Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome. BMC Neurol, 2004. 4(1): p. 2.
34.Vila, N., et al., Proinflammatory cytokines and early neurological worsening in ischemic stroke. Stroke, 2000. 31(10): p. 2325-9.

Parole Chiave

TIA, ISCHEMIA CEREBRALE, INFIAMMAZIONE, PROGNOSI, MARCATORI PERIFERICI, RICERCA MULTICENTRICA