RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - FUMO DI TABACCO, INFIAMMAZIONE E CANCRO DEL POLMONE: ASPETTI MOLECOLARI, BIOLOGICI, CLINICI E ANATOMOPATOLOGICI
• 2 - Geni dell'angiogenesi indotti da ipossia: fattori di suscettibilità nella Sclerosi Laterale Amiotrofica ?
• 3 - PROGRESSIONE DA MGUS A MIELOMA MULTIPLO: PATOGENESI MOLECOLARE, IDENTIFICAZIONE DI POTENZIALI MARCATORI PROGNOSTICI E SVILUPPO PRECLINICO DI RAZIONALI APPROCCI CHEMIOPREVENTIVI
• 4 - Sviluppo e progressione del carcinoma epatocellulare: meccanismi molecolari ed implicazioni terapeutiche
• 5 - Metodi non invasivi per lo studio delle basi biologiche e fisiopatologiche delle malattie respiratorie: applicazioni cliniche ed epidemiologiche.
• 6 - Nefrolitiasi calcica e ostepatie associate: studio delle interazioni tra cause genetiche e nutrizionali e dei meccanismi patogenetici.
• 7 - Markers clinici, genetici e molecolari della suscettibilità alla fibrillazione atriale: verso un approccio integrato della prevenzione e terapia dell'aritmia e delle sue complicanze.
• 8 - Ruolo delle adipochine, citochine infiammatorie e linfociti T regolatori nel determinismo dell’aterosclerosi accelerata e della sindrome metabolica in corso di lupus eritematoso sistemico.
• 9 - Bronchiectasie nel paziente con BPCO: prevalenza e colonizzazione batterica.
• 10 - Nuove prospettive nella fibrillazione atriale: dalla ricerca di base all'approccio terapeutico farmacologico e chirurgico.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • ANATOMIA PATOLOGICA
  • MALATTIE DELL'APPARATO RESPIRATORIO
  • CHIRURGIA TORACICA
  • MEDICINA DEL LAVORO

Classificazione brevettuale

• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]
  • TOBACCO; CIGARS; CIGARETTES; SMOKERS\' REQUISITES
    • CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • SMOKERS\' REQUISITES; MATCH BOXES (lighters F23Q)

Classificazione geografica

• Regione: Veneto

Bibliografia

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3. Croxton TL, Weinmann GG, Senior RM, Wise RA, Crapo JD, Buist AS. Clinical research in chronic obstructive pulmonary disease: needs and opportunities. Am J Respir Crit Care Med 2003; 167: 1142-1149.
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7. Peto R, Speizer FE, Cochrane AL, Moore F, Fletcher CM, Tinker CM, Higgins IT, Gray RG, Richards SM, Gilliland J, Norman-Smith B. The relevance in adults of air-flow obstruction, but not of mucus hypersecretion, to mortality from chronic lung disease. Results from 20 years of prospective observation. Am Rev Respir Dis. 1983;128:491-500.
8. Vestbo J and Lange P Can GOLD Stage 0 Provide Information of Prognostic Value in Chronic Obstructive Pulmonary Disease? Am J Respir Crit Care Med. 2002;166:329-32.
9. Vestbo J, Prescott E, Lange P, and the Copenhagen City Heart Study Group. Association between chronic mucus hypersecretion with FEV1 decline and COPD morbidity. Am J Respir Crit Care Med 1996; 153:1530–1535.
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15. Lopez-Otin C, Overall C.M. Protease degradomics: a new challenge for proteomics. Nat. Rev. Mol. Cell Biol 2002; 3, 509–519.
16. Finlay G.A., Russell K.J., McMahon K.J., Darcy E.M., Masterson J.B., FitzGerald M.Z., OConnor C.M. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997; 52, 502–506.
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18. Cataldo D., Munaut C., Noel A., Frankenne F., Bartsch P., Foidart J.M., Louis R. MMP-2-and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. Int. Arch. Allergy Immunol. 2000; 123, 259–267.
19. Vignola A.M., Riccobono L., Mirabella A., Profita M., Chanez P., Bellia V., Mautino G., D'Accardi P., Bousquet J., Bonsignore G. Sputum metalloproteinase-9 tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 1998; 158, 1945–1950.
20. Bracke Ken, Cataldo D., Maes T., Gueders M., Noel A., Foidart J.M., Brusselle G., Pauwels R. Matrix metalloproteinase-12 expression in pulmonary dendritic cells of cigarette smoke exposed mice. Int. Arch. All. Immunol. 2005; 138, 169–179.
21. Hautamaki R.D., Kobayashi D.K., Senior R.M., Shapiro S.D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997; 277, 2002–2004.
22. Hirsch J, Hansen KC, Burlingame AL, Matthay MA. Proteomics: current techniques and potential applications to lung diseases. Am J Physiol Lung Cell Mol Physiol 2004; 287: L1-L23.
23 Calabrese F, Giacometti C, Beghe B, Rea F, Loy M, Zuin R, Marulli G, Baraldo S, Saetta M, Valente M. Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema.Respir Res. 2005; 10; 6:1 4.
24. Kasahara Y, Tuder RM, Taraseviciene-Stewart L, Le Cras TD, Abman S, Hirth PK, Waltenberger J, Voelkel NF: Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000; 106: 1311-9
25. Papi A, Casoni G, Caramori G, Guzzinati I, Boschetto P, Ravenna F, Calia N, Petruzzelli S, Corbetta L, Cavallesco G, Forini E, Saetta M, Ciaccia A, Fabbri LM. COPD increases the risk of squamous histological subtype in smokers who develop non-small cell lung carcinoma. Thorax 2004; 59: 679-681
26. Hashimoto K, Kiyoshima T, Matsuo K, Ozeki S, Sakai H. Effect of SCCA1 and SCCA2 on the suppression of TNF-alpha-induced cell death by impeding the release of mitochondrial cytochrome c in an oral squamous cell carcinoma cell line. Tumor Biol 2005; 26: 165-172

Parole Chiave

BPCO, ENFISEMA, PROTEASI, DIAGNOSTICA POLMONARE PER IMMAGINI, ANALISI MOLECOLARE ED ULTRASTRUTTURALE