RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Nuove frontiere nella stratificazione delle leucemie acute linfoidi (LAL): integrazione tra citogenetica non-convenzionale, genomica e post-genomica
• 2 - Utilizzo di cellule staminali neurali tumorali come modello di studio in vitro e in vivo di glioblastoma adulto umano
• 3 - Studio degli effetti genomici dell'aldosterone in modelli cellulari ed in vivo.
• 4 - Patogenesi molecolare dei linfomi in funzione della terapia
• 5 - Eritropoiesi normale e patologica: caratterizzazione molecolare mediante tecnologie avanzate a resa elevata.
• 6 - PROGRESSIONE DA MGUS A MIELOMA MULTIPLO: PATOGENESI MOLECOLARE, IDENTIFICAZIONE DI POTENZIALI MARCATORI PROGNOSTICI E SVILUPPO PRECLINICO DI RAZIONALI APPROCCI CHEMIOPREVENTIVI
• 7 - Un modello di progressione neoplastica per il carcinoma del cavo orale: studio genomico e proteomico in vivo ed in vivo di linee cellulari e subcloni ad elevata aggressività. Correlazioni con la progressione neoplastica.
• 8 - Nuove conoscenze fisiopatologiche per nuove prospettive terapeutiche del colangiocarcinoma
• 9 - Implicazioni diagnostico-terapeutiche delle nuove conoscenze cliniche e molecolari del carcinoma midollare della tiroide.
• 10 - Aspetti biochimici e genetici del disturbo autistico.

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • ONCOLOGIA MEDICA
  • NEUROLOGIA
  • NEUROCHIRURGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • DIAGNOSIS; SURGERY; IDENTIFICATION (analysing biological material G01N, e.g. G01N33/48; obtaining records using waves other than optical waves, in general G03B42/00)

Classificazione geografica

• Regione: Sicilia

Bibliografia

Yasargil MG, Kadri PA, Yasargil DC: Microsurgery for malignant gliomas. J Neurooncol. 2004 Aug-Sep;69(1-3):67-81.
Laws ER, Shaffrey ME, Morris A, Anderson FA Jr: Surgical management of intracranial gliomas--does radical resection improve outcome?
Acta Neurochir Suppl. 2003;85:47-53
Cervoni L, Celli P, Salvati M: Long-term survival in a patient with supratentorial glioblastoma: clinical considerations.Ital J Neurol Sci. 1998 Aug;19(4):221-4
Barker FG 2nd, Chang SM, Gutin PH, Malec MK, McDermott MW, Prados MD, Wilson CB: Survival and functional status after resection of recurrent glioblastoma multiforme.
Neurosurgery. 1998 Apr;42(4):709-20
Black PM: Surgery for cerebral gliomas: past, present, and future.Clin Neurosurg. 2000;47:21-45.
Bucci MK, Maity A, Janss AJ, Belasco JB, Fisher MJ, Tochner ZA, Rorke L, Sutton LN, Phillips PC, Shu HKNear complete surgical resection predicts a favorable outcome in pediatric patients with nonbrainstem, malignant gliomas: results from a single center in the magnetic resonance imaging era. Cancer. 2004 Aug 15;101(4):817-24
Kurimoto M, Hayashi N, Kamiyama H, Nagai S, Shibata T, Asahi T, Matsumura N, Hirashima Y, Endo S: Impact of neuronavigation and image-guided extensive resection for adult patients with supratentorial malignant astrocytomas: a single-institution retrospective study.
Minim Invasive Neurosurg. 2004 Oct;47(5):278-83
Keles GE, Berger MS: Advances in neurosurgical technique in the current management of brain tumors. Semin Oncol. 2004 Oct;31(5):659-65.
Schiffbauer H, Berger MS, Ferrari P, Freudenstein D, Rowley HA, Roberts TP:Preoperative magnetic source imaging for brain tumor surgery: a quantitative comparison with intraoperative sensory and motor mapping.Neurosurg Focus. 2003 Jul 15;15
Berman JI, Berger MS, Mukherjee P, Henry RG: Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas. J Neurosurg. 2004 Jul;101(1):66-72
Keles GE, Lundin DA, Lamborn KR, Chang EF, Ojemann G, Berger MS: Intraoperative subcortical stimulation mapping for hemispherical perirolandic gliomas located within or adjacent to the descending motor pathways: evaluation of morbidity and assessment of functional outcome in 294 patients. J Neurosurg. 2004 Mar;100(3):369-75
Laws ER, Parney IF, Huang W, Anderson F, Morris AM, Asher A, Lillehei KO, Bernstein M, Brem H, Sloan A, Berger MS, Chang S; Glioma Outcomes InvestigatorsSurvival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. J Neurosurg. 2003 Sep;99(3):467-73
Keles GE, Lamborn KR, Berger MS: Coregistration accuracy and detection of brain shift using intraoperative sononavigation during resection of hemispheric tumors. Neurosurgery. 2003 Sep;53(3):556-62.
Keles GE, Lamborn KR, Berger MS: Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. J Neurosurg. 2001 Nov;95(5):735-45.
Keles GE, Anderson B, Berger MS: The effect of extent of resection on time to tumor progression and survival in patients with glioblastoma multiforme of the cerebral hemisphere.
Surg Neurol. 1999 Oct
Grasso G, Buemi M, et al. Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5627-31.
Grasso G. Erythropoiesis and neuroprotection: two sides of the same coin? Lancet Neurol. 2003 Jun;2(6):332
Erbayraktar S, Grasso G, et al. Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective
activity in vivo. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6741-6.
Leist M, Ghezzi P, Grasso G, et al. Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science. 2004 Jul 9;305(5681):239-42.
Janecka I: Erythropoietin to treat anaemia in patients with head and neck cancer. The Lancet, Volume 363, Issue 9413, Pages 993-994
Acs G, Xu X, Chu C, Acs P, Verma A Prognostic significance of erythropoietin expression in human endometrial
carcinoma Cancer. 2004 Jun 1;100(11):2376-86.
Griguer CE, et al. Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells. Cancer Res. 2006 Feb 15;66(4):2257-63.
Kaur B et al.Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro-oncol. 2005 Apr;7(2):134-53. Review.
Pinel S et al. Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts. Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):250-9.
Post DE, Van Meir EG. Generation of bidirectional hypoxia/HIF-responsive expression vectors to target
gene expression to hypoxic cells. Gene Ther. 2001 Dec;8(23):1801-7.
Grasso G, Sfacteria A et al. Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative. J Neurosurg Spine. 2006 Apr;4(4):310-8.
Buemi M, Caccamo C, Nostro L, Cavallaro E, Floccari F, Grasso G.
Brain and cancer: the protective role of erythropoietin.
Med Res Rev. 2005 Mar;25(2):245-59. Review.
Broaddus W, Liu Y, Steele LL, et al.: Enhanced radiosensitivity of malignant glioma cells after adenovirus p53 transuction. J Neurosurg 91: 997-1004, 1999
Conti A, Agennouz M, La Torre D, et al.: Expression of the tumor necrosis factor receptor-associated factors 1 and 2 and regulation of the nuclear factor-kappaB antiapoptotic activity in human gliomas. J Neurosurg 103: 873-881, 2005
Feldkamp M, Lala P, Lau N, et al.: Expression of activated epidermal growth factor receptors, Ras-guanoside triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens: Neurosurgery 45. 1442-1453, 1999
La Torre D, de Divitiis O, Conti A, Angileri FF, Cardali S, Aguennouz M, Panetta S, d'Avella D, Vita G, La Torre F, Tomasello F. Expression of telomeric repeat binding factor-1 in astroglial brain tumors. Neurosurgery. 56:802-810, 2005
Kleihues P, Burger PC, Scheithauer BW: Histological Typing of Tumor of the Central Nervous System, ed 2. Berlin: Springer-Verlag, 1993.
Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK: The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225, 2002.
Salcman M: Epidemiology and factors affecting survival, in Apuzzo MLJ (ed): Malignant Cerebral Glioma. Park Ridge, AANS, 1990, pp 95-109
Zlokovic BV, Apuzzo MJ: Cellular and molecular neurosurgery: pathways from concept to reality - Part I: Target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery 40: 789-804, 1997
Zlokovic BV, Apuzzo MJ: Cellular and molecular neurosurgery: pathways from concept to reality - Part II: Vector systems and delivering methodologies for gene therapy of the central nervous system. Neurosurgery 40: 805-813, 1997

Parole Chiave

GLIOMI CEREBRALI, MICROARRAY, GENOMA UMANO, BIOLOGIA MOLECOLARE, ERITROPOIETINA UMANA RICOMBINANTE, NEURONAVIGAZIONE, RISONANZA MAGNETICA SPETTROSCOPICA, MARKERS TUMORALI, BIOINFORMATICA