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PROGRAMMA DI RICERCA 2006
italiano - english
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- 5 - Genetica e Neuroetologia in organismi modello
- 6 - STUDI SUI FATTORI GENETICI ED IMMUNOLOGICI CHE REGOLANO IL DANNO TESSUTALE ED IL DECORSO CLINICO DELL'ARTRITE REUMATOIDE
- 7 - Interazione gene-ambiente nella psicobiologia del disturbo di panico
- 8 - Trattamento statistico della complessità e dell'incertezza negli studi ambientali
- 9 - Approccio molecolare e statistico allo studio della genetica della fertilità nel bovino da latte
- 10 - PEROSSIDAZIONE LIPIDICA, ATTIVAZIONE PIASTRINICA ED INFIAMMAZIONE ASSOCIATI A RIDOTTI LIVELLI DI LIPOPROTEINE AD ALTA DENSITA' (HDL)
Classificazione scientifico-disciplinare
- Area scientifico disciplinare: Scienze mediche
- Area scientifico disciplinare: Scienze storiche, filosofiche, pedagogiche e psicologiche
Classificazione brevettuale
- CHEMISTRY; METALLURGY
- BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
- BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- PHYSICS
- COMPUTING; CALCULATING; COUNTING (score computers for games A63; combinations of writing applicances with computing devices B43K29/08)
- COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS [N0004]
- MEASURING (counting G06M); TESTING
- INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (separating components of materials in general B01D, B01J, B03, B07; apparatus fully provided for in a single other subclass, see the relevant subclass e.g. B01L; measuring or testing processes other than immunoassay, involving enzymes or micro-organisms C12M, C12Q; investigation of foundation soil in situ E02D1/00; sensing humidity changes for compensating measurements of other variables or for compensating readings of instruments for variations in humidity, see G01D or the relevant subclass for the variable measured; testing or determining the properties of structures G01M; measuring or investigating electric or magnetic properties of materials G01R; systems or methods in general, using reception or emission of radiowaves or other waves and based on propagation effects, e.g. Doppler effect, propagation time, direction of propagation, G01S; determining sensivity, graininess, or density of photographic materials G03C5/02; testing component parts of nuclear reactors G21C17/00; [N: controlling or regulating non-electric variables G05D; measuring degree of ionisation of ionised gases, i.e. plasma H05H1/00A; testing electrographic developer properties G03G15/08H6])
- COMPUTING; CALCULATING; COUNTING (score computers for games A63; combinations of writing applicances with computing devices B43K29/08)
Bibliografia
Achenbach T.M., Dumenci L., Advances in empirically based assessment: revised cross-informant syndromes and new DSM-oriented scales for the CBCL, YSR, and TRF: comment on Lengua, Friedrich, and Fisher (2001). Journal of Consulting and Clinical Psychology, 2001,69 (4): 699-702.Akaike H: Factor analysis and AIC. Psychometrika 52: 317-332, 1987.
Almasy L, et al: Genetics of event-related potentials in response to a semantic priming paradigm in families with a history of alcoholism. Am J Hum Genet, 68:128-135, 2001.
Anokhin AP, et al: The P300 brain potential is reduced in smokers. Psychopharmacology, 149: 409-413, 2000.
Battaglia M, Bajo S, Ferini-Strambi L, Brambilla F, Castronovo C, Vanni G, Bellodi L: Physiological and behavioral responses to minor stressors in offspring of patients with panic disorders. Journal of Psychiatric Research, 31: 365-376, 1997.
Battaglia M, Ogliari A, Binaghi F, Zanoni A, Villa F, Citterio A, Fossati A, Maffei C: Children’s Discrimination of Peers’ Expressions of Emotions: Relationship with Indexes of Social Anxiety and Shyness. Journal of the American Academy of Child and Adolescent Psychiatry 43: 358-365, 2004.
Battaglia M, Ogliari A, Zanoni A., Citterio A, Pozzoli U., Maffei C., Giorda R., Marino C.: Influence of the Serotonin Transporter Promoter Gene and Shyness on Children’s Cerebral Responses to Facial Expressions. Archives of General Psychiatry 62: 85-94, 2005.
Batty M, Taylor MJ. Visual categorization during childhood: an ERP study. Psychophysiology. 2002; 39: 482-490.
Bauer LO: Frontal P300 decrements, childhood conduct disorder, family history, and the prediction of relapse among abstinent cocaine abusers. Drug and Alcohol Dependence, 44:1-10,1997.
Bauer LO, Hesselbrock VM: Subtypes of family history and conduct disorders: effects on P300 during the Stroop test. Neuropsychopharmacology, 21: 51-62, 1999.
Begleiter H., et al: ERP in boys at risk for alcoholism, Science, 225. 1493-1496, 1984
Birmaher B, et al Psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED): a replication study. J Am Acad Child Adolesc Psychiatry, 1999; 38(10):1230-6.
Blair RJ, Colledge E, Murray L, Mitchell DG: A selective impairment in the processing of sad and fearful expressions in children with psychopathic tendencies. Journal of Abnormal Child Psychology, 29:491-498, 2001.
Caldwell R, Bradley B: The relation of infants' home environments to achievement test performance in first grade: a follow-up study. Child Development. 1984 55:803-809.
Carlson SR, Iacono WG, McGue M: P300 amplitude in adolescent twins discordant and concordant for alcohol use disorders. Biological Psychology, 61:203-227, 2002.
Caspi A, et al : Role of genotype in the cycle of violence in maltreated children. Science, 297: 851-854,2002.
Cicchetti D. Developmental Psychopathology. In Cicchetti D (ed) The emergence of a discipline . (pp1-12) Rochester Symposium on Developmental Psychopathology, Vol 1. Erlbaum, Hillsdale, NJ, 1989.
Coch D, et al . Word and picture processing in children: an event-related potential study. Develop Neuropsychol. 2002; 22: 373-406.
de Geus EJC: Introduction genetic psychophysiology. Biological Psychlogy, 61: 1-10,2002.
Eaves LJ, et al : Analyzing twin resemblance in multi-symptom data: Genetic applications of a latent class model for symptoms of conduct disorder in juvenile boys. Behavior Genetics, 23: 5-20, 1993.
Falconer DS, MacLean C. Introduction to Quantitative Genetics. Essex, England:Longman Group Ltd; 1996.
Feeney, JA; Noller P Hanrahan M. Assessing adult attachment. In Sperling & Berman Attachment in Adults. Guildford, 1994 NY
Goldsmith HH & Gottesman II. Heritable variability and variable heritability in developmental psychopathology. In Lenzenweger M & Haugaard F: Frontiers of developmental psychopathology, 1996; Oxford University Press, New York.
Greene RW, et al SV: Psychiatric comorbidity, family dysfunction, and social impairment in referred youth with oppositional defiant disorder. American Journal of Psychiatry, 159:1214-1224, 2002.
Heath AC, et al . Testing structural equation models for twin data using LISREL.. Behavior Genetics 19: 9-35, 1989.
Hirshfeld-Becker DR, et al : Temperamental correlates of Disruptive Behavior Disorders in young children: preliminary findings. Biological Psychiatry, 51: 563-574, 2002.
Iacono WG, Carlson SR, Malone SM, McGue M: P3 event-related potential amplitude and the risk for disinhibitory disorders in adolescent boys. . Archives of General Psychiatry,59:750-757, 2002.
Joreskog, K.G., and Sorbom, D. LISREL 7 User’s guide. Mooresville, IN: Scientific Software, 1989.
Kagan J, Reznick JS, Gibbons J: Inhibited and uninhibited types of children. Child Development, 60: 838-845, 1989.
Kendler KS:Twin studies of psychiatric illness: current status and future directions. Archives of General Psychiatry,50:905-915, 1993.
Kendler KS, Thornton LM, Pedersen NL: Tobacco consumption in Swedish twins reared apart and reared together. Archives of General Psychiatry, 57: 886-892, 2000.
Kestenbaum R, Nelson CA. Neural and behavioral correlates of emotion recognition in children and adults. J Exp Child Psychol. 1992; 54: 1-18.
Neale MC, Cardon LR: Methodology for Genetic Studies of Twins and Families. Dordrecht, the Netherlands: Kluwer Academic Publishers; 1992.
Neale MC Mx statistical modelling VCU Box 900126 V Richmond VA., 1999.
Nobile M, Begni B, Giorda R, Frigerio A, Marino C, Molteni M Battaglia M (1999): Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 38:1396-1402.
Ogliari A, Citterio A, Zanoni A., Fagnani C, Patriarca V, Cirrincione R, Stazi MA, Battaglia M, Genetic and Envrionmental Infuences on Anxiety Dimensions in Italian Twins Evaluated with the SCARED Questionnaire. Journal of Anxiety Disorders 2006
Olivares EI, Iglesias J, Rodriguez-Holguin S. Long-latency ERPs and recognition of facial identity. J Cog Neurosi. 2003; 15: 136-151
Parker G The parental bonding Instrument. Psychiatric Developments 4: 317-335, 1989.
Plomin R, De Fries JC, & McClearn GE: Behavioral Genetics. A primer. Second Edition WH Freeman & Co., New York, 1990.
Pollak SD, et al . P3b reflects maltreated children's reactions to facial displays of emotion. Psychopsyhiology. 2001; 38: 267-274
Reich T, Cloninger CR, Guze SB: The multifactorial model of disease transmission. Description of the model and its use in psychiatry. British Journal of Psychiatry 127:1-10, 1975.
Reich W., Diagnostic interview for children and adolescents (DICA), J Am Acad Child Adolesc Psychiatry, 2000, 39(1): 59-66.
Robins LN, et al, The Composite International Diagnostic Interview, An epidemiologic Instrument suitable for use in conjunction with different diagnostic systems and in different cultures, Arch Gen Psychiatry, 45: 1069-1077. 1988;
Rosenbaum JF, Biederman J, Bolduc-Murphy EA, Faraone SV, Chaloff J, Hirshfeld-Becker DR, Kagan J: Behavioral Inhibition in childhood: a risk factor for Anxiety Disorders. Harvard Review of Psychiatry, 1:2-16,1993.
Rutter ML. Developmental Psychopathology: concepts and prospects. In Lenzenweger & Haugaard: Frontiers of developmental psychopathology pp 209-237, Oxford University Press, New York, 1996.
Rutter MR, Moffitt TE, Caspi A: Gene environment interplay and psychopathology: multiple varieties but real effects. J Child Psychology & Psychiatry 47: 226-261, 2006.
Slutske WS, Eisen S, True WR, Lyons MJ, Goldberg J, Tsuang M Common genetic vulnerability for pathological gambling and alcohol dependence in men. Archives of General Psychiatry 57: 666-673 , 2000.
Van Beijsterveldt CEM, van Baal GCM: Twin and family studies of the human electroencephalogram: a review and a meta-analisy. Biological Psychology, 61:11-138, 2002.
Parole Chiave
POTENZIALI EVOCATI, ESTERNALIZZAZIONE, INTERNALIZZAZIONE, GEMELLI, SVILUPPO, EMOZIONI, EQUAZIONI STRUTTURALIStudio elettrofisiologico e comportamentale delle condotte esternalizzate ed internalizzate in età di sviluppo: un approccio gemellare bivariato
Abstract
Le popolazioni gemellari costituiscono una risorsa unica per potere coniugare l’approccio dell’epidemiologia generale alla potenza del metodo della genetica quantitativa, permettendo così l’identificazione della natura sia genetica che ambientale di fattori di rischio e di protezione, ed il loro complesso interagire nelle dinamiche correntemente indicate col termine ‘interazione gene-ambiente’.Questo progetto si propone di indagare in uno studio gemellare bivariato le cause ultime : a) della variabilità delle manifestazioni internalizzanti ed esternalizzanti in età di sviluppo b)della variabilità di endofenotipi elettrofisiologici correlati a tali manifestazioni comportamentali c) della covariazione tra fenotipi comportamentali ed endofenotipi elettrofisologici.
Le manifestazioni internalizzanti ed esternalizzanti in età di sviluppo sono un prezioso indice predittivo di possibili manifestazioni psicopatologiche più avanti nel corso della vita.
Lo studio avverrà in circa 300 coppie afferenti ad una coorte di gemelli nati e residenti nelle provincie di Milano e di Lecco, afferenti al Registro Nazionale Italiano dei Gemelli, già parzialmente caratterizzati attraverso questionari in uno studio precedente, con parte dei risultati già pubblicati (Ogliari et al., 2006). Nello specifico, al momento sono disponibili informazioni di natura psicometria su diverse centinaia di coppie gemellari su condotte internalizzate-inibite (incluse manifestazioni di fobia >>>
Coordinatore Scientifico del Programma di Ricerca
Marco Maria Battaglia Libera Università "Vita Salute S.Raffaele" MILANOObiettivo del Programma di Ricerca
1. Analizzare i contributi quantitativi genetici e non-genetici di fenotipi comportamentali possibili precursori di psicopatologia, e delle risposte in ERP (endofenotipi) a paradigmi (classico 'oddball' e riconoscimento implicito delle espressioni delle emozioni) ad essi correlati, in un campione gemellare in età di sviluppo con approccio biomedico quantitativo basato su equazioni strutturali.2. Risolvere la natura delle relazioni tra risposte cerebrali in ERP e fenotipi esternalizzanti e internalizzanti in strutture di covarianza genetica e ambientale che permettano di calcolare entro quali termini fattori genetici o ambiental medino le correlazioni tra fenotipi comportamentali ed endofenotipi.
3. Raccoglire DNA dai gemelli e i loro familiari che consentano futuri studi di genetica molecolare.



