RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Ruolo di TRAIL/Apo-2L nella fisiopatologia emopoietica ed endoteliale
• 2 - Ruolo di TRAIL nella fisiopatologia emopoietica e vascolare
• 3 - Meccanismi fisiopatologici e possibili bersagli terapeutici nel danno vascolare.
• 4 - RIGENERAZIONE TISSUTALE MEDIANTE L'UTILIZZO DI CELLULE STAMINALI ADULTE E SUE APPLICAZIONI TERAPEUTICHE
• 5 - TERAPIA CELLULARE DELLE LESIONI SPINALI: DESTINO ED AZIONE DELLE CELLULE STAMINALI NEURALI
• 6 - RUOLO DELLE CELLULE STAMINALI NELLA RIGENERAZIONE VASCOLARE ED EPITELIALE TUBULARE DOPO DANNO DA ISCHEMIA E RIPERFUSIONE NEL TRAPIANTO RENALE
• 7 - Regolazioni epigenetiche tra cellule mesenchimali e cellule di carcinoma mammario.
• 8 - Ruolo delle cellule staminali circolanti e residenti nell'angiogenesi dei tumori renali.
• 9 - Infezioni e remodeling vascolare.
• 10 - Invecchiamento cellulare e rimodellamento vascolare

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA CLINICA
  • MALATTIE DELL'APPARATO CARDIOVASCOLARE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]

Classificazione geografica

• Regione: Lazio

Bibliografia

• Patrono C. Aspirin as an antiplatelet drug. N Engl J Med, 1994; 330: 1287-1294
• FitzGerald GA, Patrono C. The Coxibs, Selective Inhibitors of Cyclooxygenase-2. N Engl J Med, 2001; 345:433-442
• Cipollone F,Rocca B,Patrono C. Cyclooxygenase-2 Expression and Inhibition in Atherothrombosis. Arterioscler Thromb Vasc Biol, 2004; 24:246-255.
• De Caterina R, Zampolli A. From asthma to atherosclerosis-5-lipoxygenase, leukotrienes and inflammation. N Engl J Med, 2004;350:4-7.
• Romano M,Claria J. Cyclooxygenase-2 and 5-lipoxygenase converging functions of cell proliferation and tumor angiogenesis: implications for cancer therapy. FASEB J, 2003; 17:1986-95.
• Tritto I.,Ambrosio G. Spotlight on microcirculation: an update. Cardiovasc. Res. 42:600, 1999.
• Carlo Stella C.,Tabilio A. Stem cells and stem cell transplantation. Haematologica 81:573, 1996.
• Orlic D.,Kajstura J., Chimenti S., Jakoniuk I., Anderson S.M., Baosheng L.J., Pickel J., MdKay R., Nadal-Ginard B., Bodine D.M., Leri A., Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature 410:701, 2001.
• Napoli C., Quehenberger O., de Nigris F., Abete P., Glass C.K., Palinski W. Mildly oxidized low-density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells. FASEB J. 14:1996, 2000.
• Napoli C.,Ignarro L.J. Nitric oxide and atherosclerosis. Nitric Oxide 5:88, 2001.
• Jackson K.A., Majka S.M.,Wang H., Pocius J., Hartley C.J., Majesky M.W., Entman M.L., Michael L.H., Hirschi K.K., Goodell M.A. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J.Clin. Invest. 107:1395, 2001.
• Sussman M. Hearts and bones. Nature 410:640, 2001.
• Tabilio A.,Falzetti F., Giannoni C., versa F.,Martelli M.P., Rossetti M.,Caputo P.,Chionne F., ambelunghe C.,Martelli M.F. Stem cells mobilization in normal donors.
J. Hematother. 6:227, 1997.
• Carlo-Stella C.,Dotti G.,Mangoni L.,Regazzi E.,Garau D., Rizzo M.T., Savoldo B., Rizzoli V. Selection of myeloid progenitors lacking BCR-ABL mRNA in chronic myelogenous leukemia patients after in vitro treatment with the tyrosine kinase inhibitor genistein. Blood 88:3091, 1996.
• Palinski W., Napoli C. The fetal origins of atherosclerosis: Maternal hypercholesterolemia and cholesterol-lowering or antioxidant treatment during pregnancy influence in utero programming and post-natal susceptibility to the disease. FASEB J. 16:1348, 2002.
• Danos O., Mulligan R.C. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host range. Proc. Natl. Acad. Sci. (USA) 88:6460, 1988.
• MacGregor G.R., Mogg A.E., Burke J.F., Caskey C.T. Histochemical staining of clonal mammalian cell lines expressing E. Coli b-galactosidase indicates heterogeneous expression of the bacterial gene. Somat. Cell. Mol. Genet. 13:253, 1987.
• Nolan G.P., Fiering S., Nicolas J.F., Herzenberg L.A. Fluorescence-activated cell analysis sorting of viable mammalian cells based on b-D-galactosidase activity after transduction of E. Coli LacZ. Proc. Natl. Acad. Sci. (USA) 85:2603, 1988.
• Kalderon D., Roberts B.L., Richardson W.D., Smith A.E. A short amino acid sequence able to specify nuclear localization. Cell 39:499, 1984.
• D’Armiento F.P., Bianchi A., de Nigris F., Capuzzi D.M., D’Armiento M.R., Abete P., Crimi G., Palinski W., Condorelli M., Napoli C. Age-related effects on atherogenesis and scavenger enzymes of intracranial and extracranial arteries in men without classical risk factors for atherosclerosis. Stroke 32:2472, 2001.
• Napoli C., Lerman L.O., de Nigris F., Loscalzo J., Ignarro L.J. Glycoxidation of low-density lipoprotein dowregulates endothelial nitric oxide synthase in human coronary cells. J. Am. Coll. Cardiol. 40:1515, 2002.
• Napoli C., Williams-Ignarro S., de Nigris F., Lerman L.O., Rossi L., Guarino C., Mansueto G., Di Tuoro F., Pignalosa O., De Rosa G., Sica V., Ignarro L.J. Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proc. Natl. Acad. Sci. USA 101:8797, 2004.
• Ito H., Maruyama A., Iwakura K., et al. Clinical implication of the no-reflow phenomenon. A predictor of complications and left ventricular remodeling in reperfusion anterior wall myocardial infarction. Circulation 93:223, 1996.
• Wu K.C., Zerhouni E.A., Judd R.M., et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 97:765, 1998.
• Kubes P., Suzuki M., Granger D.N. Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. Am. J. Physiol. 259:G859, 1990.
• Baez S. An open cremaster muscle preparation for the study of blood vessels by in-vivo microscopy. Microvasc. Res. 5:384, 1973.
• Hill M.A., Simpson B.E., Meninger G.A. Altered cremaster muscle hemodynamic due to dysruption of the deferential feed vessels. Microvasc. Res. 39:349, 1990.
• Davis M.J. Determination of volumetric flow in capillary tubes using an optical Doppler velocimeter. Microvasc. Res. 34:223, 1987.
• Bulte J.W., Arbab A.S., Douglas T., Frank J.A. Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol. 386:275, 2004.
• Tritto I., Ambrosio G. The multi-faceted behavior of nitric oxide in vascular "inflammation": catchy terminology or true phenomenon? Cardiovasc. Res. 63:1, 2004.
• Anderson S.A., Glod J., Arbab A.S., Noel M., Ashari P., Fine H.A., Frank J.A. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood. 105:420, 2005.
• Jendelova P., Herynek V., Urdzikova L., Glogarova K., Kroupova J., Andersson B., Bryja V., Burian M., Hajek M., Sykova E. Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticle in rat brain and spinal cord. J. Neurosci. Res. 76:232, 2004.
• Frank J.A., Miller B.R., Arbab A.S., Zywicke H.A., Jordan E.K., Lewis B.K., Bryant L.H. Jr, Bulte J.W. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology. 228:480, 2003.
• Dixon B. The role of microvascular thrombosis in sepsis. Anaesth. Intensive Care. 32:619, 2004.
• Napoli C, Williams-Ignarro S, de Nigris F, de Rosa G, Lerman LO, Farzati B, Matarazzo A, Sica G, Botti C, Fiore A, Byrns RE, Sumi D, Sica V, Ignarro LJ. Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. Proc Natl Acad Sci U S A. 2005; 102:17202-6.
• Lutton A., Dewerchin M, Collen D, Carmeliet P. The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke. Curr Atheroscler Rep. 2000 Sep; 2(5): 407-16
• Masataka Sata - Circulating Vascular Progenitor cells Contribute to vascular repair, remodelling, and lesion formation - TCM 13, 249-253, 2003
• Carmen Urbich, Stefanie Dimmler- Endothelial Progenitor Cells. Functional Characterization. TCM 14, 318-322, 2004
• Holger Rumpold, Dominik Wolf, Ruth Koeck, Eberhard Gunsilius - Endothelial progenitor cells: a source for therapeutic vasculogenesis? J. Cell. Mol. Med 8, 509-518, 2004
• Manish Aghi, E. Antonio Chiocca - Contribution of Bone Marrow-Derived cells to blood vessels in Ischemic Tissues and tumors - Molecular Therapy 12, 994-1005, 2005
• Shulamit Levenberg - Engineering blood vessels from stem cells: recent advances and applications - Curr. Op. Biotechnol 16, 516-523, 2005
• Neil Roberts, Marjan Jahangiri, Qingbo Xu - Progenitor cells in vascular disease - J. Cell. Mol. Med. 9, 583-591, 2005
• Klaus Podar, Kenneth C: Anderson - The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications - Blood 105, 1383-1395, 2005
• Lee S. Rosen - VEGF-targeted therapy: therapeutic potential and recent advances - The Oncologist 10, 382-391, 2005

Parole Chiave

VASCULOPATIE, CELLULE STAMINALI, ANGIOGENESI, EICOSANOIDI