RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Influenza della variabilità del DNA mitocondriale sulla funzionalità mitocondrio-cellulare e sue conseguenze sull'invecchiamento nell'uomo.
• 2 - RUOLO DEL SEGNALE LIPIDICO NUCLEARE NEL PASSAGGIO G1/S DEL CICLO CELLULARE
• 3 - Nuove conoscenze fisiopatologiche per nuove prospettive terapeutiche del colangiocarcinoma
• 4 - Il fattore di trascrizione NF-kB nella regolazione del differenziamento ed apoptosi del sistema immune.
• 5 - Isolamento e caratterizzazione molecolare e funzionale delle cellule staminali leucemiche (LSCs) per lo sviluppo di nuove strategie terapeutiche.
• 6 - IMMUNITA' INNATA E MALATTIA CELIACA
• 7 - Medulloblastoma: studio delle vie molecolari di sviluppo e progressione tumorale allo scopo di identificare approcci terapeutici innovativi
• 8 - COMPLICANZE OSTETRICHE DA ANTICORPI ANTI-FOSFOLIPIDI: meccanismi patogenetici molecolari quali nuovi target terapeutici e marcatori prognostici.
• 9 - Regolazione della massa e della funzione beta-cellulare nel diabete mellito di tipo 2: meccanismi di danno e strategie riparative
• 10 - IL POSTCONDIZIONAMENTO: MODALITA' DI PROTEZIONE DEL MIOCARDIO CONTRO I DANNI DA ISCHEMIA E RIPERFUSIONE

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • PATOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Emilia Romagna

Bibliografia

1. Achanta G, Sasaki R, Feng L, Carew JS, Lu W, Pelicano H, Keating MJ, Huang P. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J. 2005;24(19):3482-92.
2. Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 2001;20(8):1910-20.
3. Bonafe M, Barbi C, Storci G et al. What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians. Exp Gerontol. 2002;37:1263-1271.
4. Bonafe M, Salvioli S, Barbi C, et al. The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ. 2004;11(9):962-73.
5. Carew JS, Zhou Y, Albitar M, Carew JD, Keating MJ, Huang P. Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia. 2003;17(8):1437-47.
6. Cargill M, Altshuler D, Ireland J et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999;22:231-238.
7. Chakravarti A. Population genetics--making sense out of sequence. Nat Genet. 1999;21:56-60.
8. Chen D, Yu Z, Zhu Z, Lopez CD. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Res. 2006;66(7):3485-94.
9. Chen XJ, Butow RA. The organization and inheritance of the mitochondrial genome. Nat Rev Genet. 2005;6(11):815-25.
10. Chen D, Yu Z, Zhu Z, Lopez CD. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.Cancer Res. 2006;66(7):3485-94.
11. Chen D, Cao G, Hastings T, Feng Y, Pei W, O'Horo C, Chen J. Age-dependent decline of DNA repair activity for oxidative lesions in rat brainmitochondria. J Neurochem. 2002;81(6):1273-84.
12. Chomyn A, Attardi G. MtDNA mutations in aging and apoptosis. Biochem Biophys Res Commun. 2003;304(3):519-29.
13. Copeland WC, Ponamarev MV, Nguyen D, Kunkel TA, Longley MJ. Mutations in DNA polymerase gamma cause error prone DNA synthesis in human mitochondrial disorders. Acta Biochim Pol. 2003;50(1):155-67.
14. Cossarizza A, Riva A, Pinti M, Ammannato S, Fedeli P, Mussini C, Esposito R, Galli M. Increased mitochondrial DNA content in peripheral blood lymphocytes from HIV-infected patients with lipodystrophy. Antivir Ther. 2003;8(4):315-21.
15. de Souza-Pinto NC, Harris CC, Bohr VA. p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene. 2004;23(39):6559-68.
16. Dumont P, Leu JIJ, Della Pietra III AC, Donna L.George and Maureen Murphy (2003) The codon 72 polymorphic variants of p53 demonstrate significant differences in apoptotic potential. Nat. Genet. 33: 357-365
17. Heyne K, Mannebach S, Wuertz E, Knaup KX, Mahyar-Roemer M, Roemer K. Identification of a putative p53 binding sequence within the human mitochondrial genome. FEBS Lett. 2004 3;578(1-2):198-202.
18. Kaguni LS. DNA polymerase gamma, the mitochondrial replicase. Annu Rev Biochem. 2004;73:293-320.
19. Kang D, Hamasaki N. Maintenance of mitochondrial DNA integrity: repair and degradation. Curr Genet. 2002;41(5):311-22.
20. Karthikeyan G, Resnick MA. Impact of mitochondria on nuclear genome stability. DNA Repair (Amst). 2005;4(2):141-8.
21. Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309(5733):481-4.
22. Mahyar-Roemer M, Fritzsche C, Wagner S, Laue M, Roemer K. Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells. Oncogene. 2004;23(37):6226-36.
23. Marchenko ND, Zaika A, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem. 2000;275(21):16202-12.
24. Marin MC, Jost CA, Brooks LA, et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat. Genet. 2000; 25: 47-54
25. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11(3):577-90.
26. Nekhaeva E, Bodyak ND, Kraytsberg Y, McGrath SB, Van Orsouw NJ, Pluzhnikov A, Wei JY, Vijg J, Khrapko K. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A. 2002;99(8):5521-6.
27. Pietsch EC, Humbey O, Murphy ME. Polymorphisms in the p53 pathway.Oncogene. 2006;25(11):1602-11.
28. Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis.FEBS Lett. 1997;411(1):77-82.
29. Salvioli S, Bonafe M, Barbi C et al. p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1. Cell Cycle. 2005;4:1264-1271.
30. Siddique M, Sabapathy K. Trp53-dependent DNA-repair is affected by the codon 72 polymorphism. Oncogene. 2006 Feb 6; [Epub ahead of print]
31. Singh KK. Mitochondria damage checkpoint in apoptosis and genome stability. FEMS Yeast Res. 2004;5(2):127-32.
32. Storey A, Thomas M, Kalita A, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998; 393: 229-234
33. Sullivan A, Syed N, Gasco M, et al. Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene. 2004;23(19):3328-37.
34. Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood TB, Turnbull DM. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest. 2003;112(9):1351-60.
35. Thomas M, Kalita A, Labrecque S, Pim D, Banks L, Matlashewski G. Two polymorphic variants of wild-type p53 differ biochemically and biologically. Mol. Cell. Biol. 1999; 19: 1092-1100
36. Thomas M, Pim D, Banks L. The role of the E6-p53 interaction in the molecular pathogenesis of HPV. Oncogene. 1999;18:7690-7700.
37. Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004; 429(6990):417-23.
38. Van Goethem G, Martin JJ, Van Broeckhoven C. Progressive external ophthalmoplegia and multiple mitochondrial DNA deletions. Acta Neurol Belg. 2002;102(1):39-42.
39. van Heemst D, Mooijaart SP, Beekman M, et al. Variation in the human TP53 gene affects old age survival and cancer mortality. Exp Gerontol. 2005; 40(1-2):11-5.
40. Zhang J, Asin-Cayuela J, Fish J, et al. Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A. 2003;100(3):1116-21.

Parole Chiave

DNA MITOCONDRIALE, POLIMORFISMO DI P53, ACCUMULO DI MUTAZIONI, LONGEVITÀ UMANA, POLIMERASI GAMMA