RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Sviluppo di nuovi bioinsetticidi
• 2 - Meccanismi della citochinesi: identificazione di nuovi geni coinvolti nel processo e nella sua regolazione
• 3 - Caratterizzazione molecolare di factori di virulenza di Helicobacter pylori
• 4 - Basi genetiche e molecolari della patogenicità batterica
• 5 - Basi metaboliche e molecolari della sindrome di Down
• 6 - Il fattore di trascrizione NF-kB nella regolazione del differenziamento ed apoptosi del sistema immune.
• 7 - Ruolo, Meccanismi molecolari e nuovi interattori delle proteine Prep/Meis/Pbx nello sviluppo embrionale.
• 8 - Eritropoiesi normale e patologica: caratterizzazione molecolare mediante tecnologie avanzate a resa elevata.
• 9 - Caratterizzazione molecolare dell'eritropoiesi:analisi post-genomica e funzionale del profilo di espressione proteica
• 10 - Delucidazione delle basi molecolari della infertilità femminile

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • MICROBIOLOGIA E MICROBIOLOGIA CLINICA
• Area scientifico disciplinare: Scienze biologiche
  • GENETICA
  • MICROBIOLOGIA GENERALE

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)

Classificazione geografica

• Regione: Veneto

Bibliografia

Bishai, W. R. & . (1998). The Mycobacterium tuberculosis genomic sequence: anatomy of a master adaptor. Trends Microbiol 6, 464-465.

Bonanni, D., Rindi, L., Lari, N. & Garzelli, C. (2005). Immunogenicity of mycobacterial PPE44 (Rv2770c) in Mycobacterium bovis BCG-infected mice. J Med Microbiol 54, 443-448.

Brodin, P., Rosenkrands, I., Andersen, P., Cole, S. T. & Brosch, R. (2004). ESAT-6 proteins: protective antigens and virulence factors? Trends Microbiol 12, 500-508.

Canneva, F., Branzoni, M., Riccardi, G., Provvedi, R. & Milano, A. (2005). Rv2358 and FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc. J Bacteriol 187, 5837-5840.

Cappelli, G., Volpe, E., Grassi, M., Liseo, B., Colizzi, V. & Mariani, F. (2006). Profiling of Mycobacterium tuberculosis gene expression during human macrophage infection: Upregulation of the alternative sigma factor G, a group of transcriptional regulators, and proteins with unknown function. Res Microbiol.

Cole, S. T., Brosch, R., Parkhill, J. & other authors (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393, 537-544.

Converse, S. E. & Cox, J. S. (2005). A protein secretion pathway critical for Mycobacterium tuberculosis virulence is conserved and functional in Mycobacterium smegmatis. J Bacteriol 187, 1238-1245.

Dainese, E., Rodrigue, S., Delogu, G. & other authors (2006). Posttranslational Regulation of Mycobacterium tuberculosis Extracytoplasmic-Function Sigma Factor {sigma}L and Roles in Virulence and in Global Regulation of Gene Expression. Infect Immun 74, 2457-2461.

Darwin, A. J. (2005). The phage-shock-protein response. Mol Microbiol 57, 621-628.
Demangel, C., Brodin, P., Cockle, P. J., Brosch, R., Majlessi, L., Leclerc, C. & Cole, S. T. (2004). Cell Envelope Protein PPE68 Contributes to Mycobacterium tuberculosis RD1 Immunogenicity Independently of a 10-Kilodalton Culture Filtrate Protein and ESAT-6. Infect Immun 72, 2170-2176.

Dieli, F., Troye-Blomberg, M., Ivanyi, J. & other authors (2001). Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes. J Infect Dis 184, 1082-1085.

Dubrac, S. & Touati, D. (2000). Fur positive regulation of iron superoxide dismutase in Escherichia coli: functional analysis of the sodB promoter. J Bacteriol 182, 3802-3808.

Ferrara, G., Losi, M., Meacci, M. & other authors (2005). Routine hospital use of a new commercial whole blood interferon-gamma assay for the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 172, 631-635.

Gey Van Pittius, N. C., Gamieldien, J., Hide, W., Brown, G. D., Siezen, R. J. & Beyers, A. D. (2001). The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria. Genome Biol 2, RESEARCH0044.

Giacomini, E., Sotolongo, A., Iona, E. & other authors (2006). The infection of human dendritic cells with a Mycobacterium tuberculosis sigE mutant stimulates a high production of IL-10 and low expression of CXCL10: impact on T cell response. Infect Immun Accepted for publication.

Hall, H. K. & Foster, J. W. (1996). The role of fur in the acid tolerance response of Salmonella typhimurium is physiologically and genetically separable from its role in iron acquisition. J Bacteriol 178, 5683-5691.

Hestvik, A. L., Hmama, Z. & Av-Gay, Y. (2005). Mycobacterial manipulation of the host cell. FEMS Microbiol Rev 29, 1041-1050.

Hsu, T., Hingley-Wilson, S. M., Chen, B. & other authors (2003). The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A 100, 12420-12425.

Loprasert, S., Sallabhan, R., Whangsuk, W. & Mongkolsuk, S. (2000). Characterization and mutagenesis of fur gene from Burkholderia pseudomallei. Gene 254, 129-137.

Manganelli, R., Dubnau, E., Tyagi, S., Kramer, F. R. & Smith, I. (1999). Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol 31, 715-724.

Manganelli, R., Voskuil, M. I., Schoolnik, G. K. & Smith, I. (2001). The Mycobacterium tuberculosis ECF sigma factor SigE: role in global gene expression and survival in macrophages. Mol Microbiol 41, 423-437.

Manganelli, R., Voskuil, M. I., Schoolnik, G. K., Dubnau, E., Gomez, M. & Smith, I. (2002). Role of the extracytoplasmic-function Sigma Factor SigH in Mycobacterium tuberculosis global gene expression. Mol Microbiol 45, 365-374.

Manganelli, R., Fattorini, L., Tan, D., Iona, E., Orefici, G., Altavilla, G., Cusatelli, P. & Smith, I. (2004a). The Extra Cytoplasmic Function Sigma Factor SigE Is Essential for Mycobacterium tuberculosis Virulence in Mice. Infect Immun 72, 3038-3041.

Manganelli, R., Provvedi, R., Rodrigue, S., Beaucher, J., Gaudreau, L. & Smith, I. (2004b). Sigma factors and global gene regulation in Mycobacterium tuberculosis. J Bacteriol 186, 895-902.

Milano, A., Branzoni, M., Canneva, F., Profumo, A. & Riccardi, G. (2004). The Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. Res Microbiol 155, 192-200.

Ochsner, U. A. & Vasil, M. L. (1996). Gene repression by the ferric uptake regulator in Pseudomonas aeruginosa: cycle selection of iron-regulated genes. Proc Natl Acad Sci U S A 93, 4409-4414.

Oku, Y., Kurokawa, K., Ichihashi, N. & Sekimizu, K. (2004). Characterization of the Staphylococcus aureus mprF gene, involved in lysinylation of phosphatidylglycerol. Microbiology 150, 45-51.

Panina, E. M., Mironov, A. A. & Gelfand, M. S. (2003). Comparative genomics of bacterial zinc regulons: enhanced ion transport, pathogenesis, and rearrangement of ribosomal proteins. Proc Natl Acad Sci U S A 100, 9912-9917.

Raviglione, M. C. (2003). The TB epidemic from 1992 to 2002. Tuberculosis (Edinb) 83, 4-14.

Rindi, L., Bonanni, D., Lari, N. & Garzelli, C. (2004). Requirement of gene fadD33 for the growth of Mycobacterium tuberculosis in a hepatocyte cell line. New Microbiol 27, 125-131.

Sala, C., Forti, F., Di Florio, E., Canneva, F., Milano, A., Riccardi, G. & Ghisotti, D. (2003). Mycobacterium tuberculosis FurA autoregulates its own expression. J Bacteriol 185, 5357-5362.

Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003). Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48, 77-84.

Smith, I. (2003). Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 16, 463-496.

Staubitz, P., Neumann, H., Schneider, T., Wiedemann, I. & Peschel, A. (2004). MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance. FEMS Microbiol Lett 231, 67-71.

Voskuil, M. I., Schnappinger, D., Visconti, K. C., Harrell, M. I., Dolganov, G. M., Sherman, D. R. & Schoolnik, G. K. (2003). Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med 198, 705-713.

Weidenmaier, C., Kristian, S. A. & Peschel, A. (2003). Bacterial resistance to antimicrobial host defenses--an emerging target for novel antiinfective strategies? Curr Drug Targets 4, 643-649.

Zhang, Z., Gosset, G., Barabote, R., Gonzalez, C. S., Cuevas, W. A. & Saier, M. H., Jr. (2005). Functional interactions between the carbon and iron utilization regulators, Crp and Fur, in Escherichia coli. J Bacteriol 187, 980-990.

Parole Chiave

MICROBIOLOGIA, MICOBATTERI, REGOLAZIONE DELLA TRASCRIZIONE, TUBERCOLOSI, GENOMICA FUNZIONALE, VIRULENZA, GENETICA BATTERICA, PLASMIDI, MYCOBACTERIUM TUBERCULOSIS