RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - ADIPOSITA' E BILANCIO ENERGETICO:FATTORI ENDOCRINI, MECCANISMI CELLULARI ED ASPETTI FISIO-PATOLOGICI
• 2 - Effetti di rosiglitazone e metformina sullo sviluppo e la progressione dell'insufficienza cardiaca cronica in un modello di insulino-resistenza e scompenso cardiaco
• 3 - PEROSSIDAZIONE LIPIDICA, ATTIVAZIONE PIASTRINICA ED INFIAMMAZIONE ASSOCIATI A RIDOTTI LIVELLI DI LIPOPROTEINE AD ALTA DENSITA' (HDL)
• 4 - Ruolo delle adipochine, citochine infiammatorie e linfociti T regolatori nel determinismo dell’aterosclerosi accelerata e della sindrome metabolica in corso di lupus eritematoso sistemico.
• 5 - Studio degli effetti genomici dell'aldosterone in modelli cellulari ed in vivo.
• 6 - EFFETTI MOLECOLARI PLEIOTROPI DELLA INIBIZIONE DELLA PDE5
• 7 - Aspetti biochimici e genetici del disturbo autistico.
• 8 - Obesità e infiammazione nel bambino: aspetti genetici, fisiopatologici e fenotipici.
• 9 - Ruolo patogenetico del Brain-derived neurotrophic factor (BDNF) nell'eziologia delle patologie neurodegenerative: dai modelli animali allo studio nell'uomo.
• 10 - Iperlipidemia, Aterosclerosi e Insufficienza Renale

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • MEDICINA INTERNA
  • MALATTIE DELL'APPARATO CARDIOVASCOLARE
  • PEDIATRIA GENERALE E SPECIALISTICA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
• HUMAN NECESSITIES
  • MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • DIAGNOSIS; SURGERY; IDENTIFICATION (analysing biological material G01N, e.g. G01N33/48; obtaining records using waves other than optical waves, in general G03B42/00)
    • PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES (bringing into special physical form A61J [N: mechanical aspects]; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; compounds per se C01, C07, C08, C12N; soap compositions C11D; micro-organisms per se C12N) [C0203]
    • THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Classificazione geografica

• Regione: Campania

Bibliografia

1-Sokol RJ. 2000 The chronic disease of childhood obesity: the sleeping giant has awakened (editorial). J Pediatr. 136: 711-13
2- Dietz WH, Robinson TN. 2005 Overweight children and adolescents. N Engl J Med 352: 2100-9.
3- Berenson GS, Srinivasan SR, Bao W et al. 1998 Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med. 338: 1650-6
4- Cook S, Weitzman M, Auinger P et al. 2003 Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med.157: 821-7
5- Weiss R, Dziura J, Burgert TS et al. 2004 Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 350: 2362-74
6- St. Jeor ST, Hayman LL, Daniels SR et al. 2004 Obesity, a worldwide epidemic related to heart disease and stroke group II: age-dependent risk factors for obesity and comorbidities. Circulation 110: e471-e475.
7- Wong CY, O'Moore-Sullivan T, Leano R et al. 2004 Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 110:3081-3087.
8- Sutherland GR, Di Salvo G, Claus P, D'hooge J, Bijnens B. 2004 Strain and strain rate imaging: a new clinical approach to quantifying regional myocardial function. J Am Soc Echocardiogr 17:788-802.
9- Urheim S, Edvardsen T, Torp H, Angelsen B, Smiseth OA. 2000 Myocardial strain by Doppler echocardiography: validation of a new method to quantify regional myocardial function. Circulation 102:1158 -1164.
10- Greenberg NL, Firstenberg MS, Castro PL et al. 2002 Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. Circulation 105:99-105.
11- Weidemann F, Eyskens B, Jamal F et al. 2002 Quantification of regional left and right ventricular radial and longitudinal function in healthy children using ultrasound based strain rate and strain imaging. J Am Soc Echocardiogr 15: 20-28.
12- Weidemann F, Eyskens B, Mertens L et al. 2002 Quantification of regional right and left ventricular function by ultrasonic strain rate and strain indexes after surgical repair of tetralogy of Fallot. Am J Cardiol. 90:133-138.
13- Di Salvo G, Drago M, Pacileo G et al. 2005 Comparison of strain rate imaging for quantitative evaluation of regional left and right ventricular function after surgical versus percutaneous closure of atrial septal defect. Am J Cardiol. 96:299-302.
14- Weidemann F, Eyskens B, Sutherland GR. 2002 New ultrasound methods to quantify regional myocardial function in children with heart disease. Pediatr Cardiol. 23:292-306.
15- Cook BB, Trelber FA, Mensah G, Jindal M, Davis HC, Kapuku GK 2001 Family history of hypertension and left ventricular mass in youth: possible mediating parameters. AJH 14: 351-356.
16- Lurbe E, Alvarez V, Liao Y et al. 1998 The impact of obesity and body fat distribution on ambulatory blood pressure in children and adolescents. AJH 11: 418-424.
17- Ferrannini E. 2005 Insulin and blood pressure, connected on a circumference? Hypertension 45: 1-2
18- Hanevold C, Waller J, Daniels S, Portman R, Sorof J. 2004 The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the international pediatric hypertension association. Pediatrics 113: 328-333.
19- De Simone G, Devereux RB, Daniels SR et al. 1995 Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol 25: 1056-62.
20- Gutin B, Treiber F, Owens S, Mensah G, 1998 Relations of body composition to left ventricular geometry and function in children. J Pediatr 132: 1023-7.
21- de las Fuentes L, Herrero P, Peterson LR et al. 2003 Myocardial fatty acid metabolism independent predictor of left ventricular mass in hypertensive heart disease. Hypertension 41: 83-87.
22- Awan MM and Saggerson ED 1993 Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation. Biochem J 295: 61–66
23- Gamble J and Lopaschuk GD 1997 Insulin inhibition of 5 adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation. Metabolism 46: 1270–1274
24- Dyck DJ, Steinberg G, and Bonen A 2001 Insulin increases FFA uptake and esterification but reduces lipid utilization in isolated contracting muscles. Am J Physiol Endocrinol Metab 281: E600– E607
25- Peterson LR, Herrero P, Schechtman KB et al. 2004 Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109: 2191-2196.
26- Panza JA, Quyyumi AA, Brush JE Jr, Epstein SE. 1990 Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 323:22-27.
27- Perticone F, Ceravolo R, Pujia A et al. 2001 Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 104:191-196.
28- Zeng G, Nystrom FH, Ravichandran LV et al. 2000 Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation. 101:1539-1545
29- Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G. 2004 Angiotensin II impairs the insulin signalling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser 616 in human umbilical vein endothelial cells. Circ Res 94:1211-8
30- Reaven GM 1988 Banting lecture 1988. Role of insulin resistance in human disease.
Diabetes. 37: 1595-607
31- McGarry JD 2002 Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 51: 7-18
32- Malecki MT 2005 Genetics of type 2 diabetes mellitus. Diabetes Res Clin Pract.; 68: Suppl 1, S10-21.
33- Le Fur S, Le Stunff C, Bougneres P 2002 Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. Diabetes.; 51: S304-7.
34- Bouchard L, Weisnagel SJ, Engert JC et al. 2004 Human resistin gene polymorphism is associated with visceral obesity and fasting and oral glucose stimulated C-peptide in the Quebec Family Study. J Endocrinol Invest. 27:1003-9.
35- Ma X, Warram JH, Trischitta V, Doria A. 2002 Genetic variants at the resistin locus and risk of type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 87:4407-10.
36- Guettier JM, Georgopoulos A, Tsai MY et al. 2005 Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein C-III genes are associated with the metabolic syndrome and dyslipidemia in a South Indian population. J Clin Endocrinol Metab. 90:1705-11.
37- Kao WH, Coresh J, Shuldiner AR, Boerwinkle E, Bray MS, Brancati FL. 2003 Atherosclerosis Risk in Communities Study. Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study.
Diabetes 52:1568-72.
38- Ceravolo R, Maio R, Cuda G et al 2003 Relation of fasting insulin related to insertion/deletion polymorphism of angiotensin-converting enzyme-gene and cardiac mass in never-treated patients with systemic hypertension. Am J Cardiol. 92:1234-7
39- George J. 2006 Angiopoietin-like proteins: another player in the metabolic field. Journal of Hepatology 44: 832-834.
40- Oike Y, Akao M, Kubota Y, Suda T. 2005 Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends in Molecular Medicine 11: 473-479.
41- Oike Y, Akao M, Yasunaga K et al. 2005 Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nature Medicine 11: 400-408.

Parole Chiave

OBESITÀ, DANNO CARDIOVASCOLARE, INSULINO RESISTENZA, OMEOSTASI GLICEMICA, POLIMORFISMI GENICI, FUNZIONE MIOCARDIACA, ANGIOPOIETIN-LIKE PROTEINE, DOPPLER TISSUTALE, SPESSORE MEDIO INTIMALE