RICERCA ITALIANA     

Programmi di ricerca simili:

• 1 - Basi metaboliche e molecolari della sindrome di Down
• 2 - IDENTIFICAZIONE DI NUOVI GENI MALATTIA MEDIANTE ANALISI DEL TRASCRITTOMA (TOM: TRANSCRIPTOME OF MIM)
• 3 - Aspetti biochimici e genetici del disturbo autistico.
• 4 - Geni dell'angiogenesi indotti da ipossia: fattori di suscettibilità nella Sclerosi Laterale Amiotrofica ?
• 5 - Patogenesi molecolare ed analisi sequenziale di interazioni cellulari e marcatori biologici di progressione di malattia e di resistenza al trattamento nella leucemia linfatica cronica
• 6 - DISSEZIONE DEI FATTORI GENETICI E COMPRENSIONE DEI MECCANISMI RESPONSABILI DEL DIABETE AUTOIMMUNE
• 7 - Meccanismi della citochinesi: identificazione di nuovi geni coinvolti nel processo e nella sua regolazione
• 8 - Analisi delle mappe trascrizionali e delle variazioni di moduli funzionali nel corso del differenziamento mieloide umano normale
• 9 - Patogenesi molecolare delle malattie del motoneurone come tool per l’identificazione di nuovi approcci terapeutici biomolecolari e cellulari
• 10 - IDENTIFICAZIONE DI GENI COINVOLTI NELLA DETERMINAZIONE DI PATOLOGIE RENALI MALFORMATIVE: DALL'IPOTESI PATOGENETICA ALL'ANALISI MUTAZIONALE

Classificazione scientifico-disciplinare

• Area scientifico disciplinare: Scienze mediche
  • GENETICA MEDICA
  • NEFROLOGIA

Classificazione brevettuale

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

Classificazione geografica

• Regione: Puglia

Bibliografia

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2.Gesualdo L, Di Palma AM, Morrone LF, Strippoli GF, Schena FP. The Italian experience of the national registry of renal biopsies. Kidney Int 2004, 66: 890-894
3.Schena FP & the Italian Group of Renal Immunopathology (1997) Survey of the Italian Registry of renal biopsies. Frequency of renal diseases for 7 consecutive years. Nephrol Dial Transplant 12:418-426
4.Rivera F, López-Gómez J M, Pérez-García R representing the Spanish Registry of Glomerulonephritis (2002) Frequency of renal pathology in Spain 1994-1999. Nephrol Dial Transplant 17:1594-1602
5.Briganti EM, Atkins RC, Chadban SJ (2003) Albuminuria and renal insufficiency prevalence guides population screening. Kidney Int 64:761-762
6.Schena FP (1990) A retrospective analysis of the natural history of primary IgA nephropathy worldwide. Am J Med 89:209-215
7.Kabasakal C, Keskinoglu A, Mir S, Basdemir G (1997) IgA nephropathy occurring in two siblings of three families. Turk J Pediatr 39:395-401
8.Scolari F (2003) Inherited forms of IgA nephropathy. J Nephrol 16:317-320
9.Scolari F, Amoroso A, Savoldi S (1999) Familial clustering of IgA nephropathy: further evidence in an Italian population. Am J Kidney Dis 33: 857-865
10.Schena FP, Scivittaro V, Ranieri E. IgA nephropathy: pros and cons for a familial disease. Contrib Nephrology 1993, 104: 36-45
11.Schena FP, Cerullo G, Rossini M, Lanzilotta SG, D’Altri C, Manno C (2002) Increased risk of end-stage renal disease in familial IgA nephropathy. J Am Soc Nephrol 13: 453-460
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18.Schena FP . Immunogenetic aspects of primary IgA nephropathy. Kidney Int 1995, 48: 1998-2013
19.Egido J, Julian BA, Wyatt RJ. Genetic factors in primary IgA nephropathy. Nephrol Dial Transplant 1987, 2: 134-142
20.Gharavi AG, Yan Y, Scolari F, Schena FP, Frasca GM, Ghiggeri GM, Cooper K, Amoroso A, Viola BF, Battini G, Caridi G, Canova C, Farhi A, Subramanian V, Nelson-Williams C, Woodford S, Julian BA, Wyatt RJ, Lifton RP. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genetics 2000, 26:354-357
21.Bisceglia L, Cerullo G, Torres D D, Scolari F, Di Perna M, Foramitti M, Amoroso A, Bertok S, Floege J, Mertens P R, Zerres K, Alexopoulos E, Kirmizis D, Mazzucco E, Zelante L and Schena F P on behalf of the European IgA Nephropathy Consortium. Genetic heterogeneity in Italian IgA nephropathy families: evidence of two novel IgAN loci. Am J Hum Genet 2006 (submitted)
22.Mayeux R. Mapping the new frontier: complex genetic disorders. J Clin Invest 2005, 115: 1404-1407.
23.Schena FP, Cerullo G, Torres DD, Scolari F, Foramitti M, Amoroso A, Pirrulli D, Floege J, Mertens PR, Zerres K, Alexopoulos E, Kirmizis D, Zelante L, Bisceglia L, Ghiggeri GM, Frasca GM, The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait. BMC Nephrol 2005; 6: 14
24.Schena FP , Cerullo G, Torres DD, Scolari F, Foramitti, Amoroso A, Pirulli D, Floege J, Mertens PR, Zerres K, Alexopoulos E, Kirmizis D, Zelante L, Bisceglia L. Role of interferon-gamma gene polymorphisms in susceptibility to IgA nephropathy: a family –based association study. Eur J Hum Genet 2006, 4: 488-496.
25. Pirulli D, Ulivi S, Zadro C, Bertok S, Crovella S, Scolari F, ForamittiM ,Ravani P, Roccatello D, Savoldi S, Cerullo G, Lanzilotta SG, Bisceglia L, Zelante L, Floege J, Mertens P, Zerres K, Alexopoulos E, Kirmizis D, Ghiggeri GM, Frasca G, Schena FP, and Amoroso A on behalf of the European IgAN Consortium. Polymorphisms In The Gene Coding For The Core1 β 1,3-Galactosyltransferase T1 Contribute To The Genetic Susceptibility To IgA Nephropathy. Nephrol Dial Transplant 2006, final revision
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27.Freudenberg J, Propping P.A similarity-based method for genome-wide prediction of disease-relevant human genes.Bioinformatics, 2002;2:S110-5.
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29. Lopez-Bigas N, Ouzounis CA.Genome-wide identification of genes likely to be involved in human genetic disease. Nucleic Acids Res, 2004;32:3108-14.
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Parole Chiave

COLLEZIONAMENTO DELL'RNA E DEL DNA, ESPRESSIONE GENICA, ANALISI CON MICROARRAY, SILENZIAMENTO GENICO, GENOMICA FUNZIONALE, STUDI DI ASSOCIAZIONE, BIOINFORMATICA, MALATTIA GENETICA COMPLESSA, IGA NEFROPATIA