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RESEARCH PROGRAM
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Research Units
Similar research programs:
- 1 - CYCLOADDITIONS WITH REDUCED ENVIRONMENTAL IMPACT FOR THE SYNTHESIS OF PRODUCTS OF BIOLOGICAL INTEREST
- 2 - Catalytic/photocatalytic oxidative activation in organic synthesis
- 3 - Direct synthesis of H2O2 and its integrated use in nanoconfined systems
- 4 - Product oriented chemo- and stereo-selective syntheses by innovative transition metal catalysts
- 5 - NON-AROMATIC HETEROCYCLES IN STEREOCONTROLLED PROCESSES
- 6 - Oxidative activation of organic molecules through new catalytic and photocatalytic processes
- 7 - New eco-sustainable catalytic processes based on the synthesis of H2O2 from H2/O2 and its integrated use in selective oxidation and depuration of emission processes.
- 8 - Regio- and enantioselective reactions mediated by transition metal catalysts for innovative processes in fine chemicals synthesis
- 9 - STEREOCONTROLLED SYNTHESIS OF ORGANIC MOLECULES USING INNOVATIVE AND PRACTICAL METHODS
- 10 - SYNTHESIS AND STEREOCONTROL OF ORGANIC MOLECULES FOR THE DEVELOPMENT OF INNOVATIVE AND PRACTICAL METHODS
Scientific and education field classification
International Patent Classification
- CHEMISTRY; METALLURGY
- ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
- GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)
- ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
Geographical classification
- Region: Puglia
Bibliografia
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10. Aresta, M.; Dibenedetto, A., J. Mol. Catal. 2002, 182-183, 399-409.
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Keywords
SEQUENTIAL SYNTHESES, ORGANIC CARBONATES, CARBAMATES AND ISOCYANATES, ASYMMETRIC AND SYMMETRIC UREAS, LACTONES AND BUTENOLYDES, OPTICALLY ACTIVE COMPOUNDS, REACTIONS OF OLEFINS, ACRYLIC ACIDS, NANO-STRUCTURED CATALYSTSDesign and development of molecular or nano-structured catalysts and sustainable (high yield and selectivity) synthetic strategies for the synthesis of complex molecular compounds from eco-friendly building blocks.
Università degli Studi di BariAbstract
This Project is aimed at developing new synthetic methodologies of complex-multifunctional molecules for which there is a need of developing new strategies responding to the basic principles of sustainability. The new syntheses will:• avoid the use of toxic products,
• reduce the use of organic solvents (avoiding halogenated solvents),
• introduce the concept of solvent-reagent in order to simplify the reaction system,
• operate at the lowest possible temperature in order to save energy,
• be driven by efficient nano-structured or novel-concept molecular catalysts able to organize the sequential reaction of several substrates.
As a result, syntheses characterized by high yield and selectivity are expected, which will have a lower environmental impact of those on stream while producing higher benefits to Industry. The target molecules are either fine chemicals or intermediates or products used by the Chemical and/or Pharmaceutical Industry. They have been selected among those that already have a large market, under further expansion because of new uses of the product, and need an urgent innovation of the synthetic technologies because those on stream cause a negative environmental impact, being based on the use of toxic compounds (banned in several Countries) or produce large amounts of toxic waste.
The goals of this Project are to develop syntheses that:
• avoid the use of phosgene in the synthesis of organic >>>
Principal Investigator
Michele Aresta Università degli Studi di BARIResearch Objectives
The increased pressure on manufacturers to produce chemicals meeting the Kyoto Protocol [1] and the EU Policies for the Chemical Industry and the Protection of Human Health [2] has led to an urgent demand for alternative environmentally friendly processes. New approaches to catalysis (key to over 80% of the actual chemical production) are based on the key issues categorized below.• Development of new, highly efficient catalysts characterized by excellent selectivity and long lifetime.
• Utilization of new reaction means, alternative to conventional solvents, with total elimination of chlorinated solvents.
• New synthetic methodologies characterized by low carbon-intensity.
• Substitution of toxic compounds with less noxious ones.
• Reduction of production costs by reducing the amount of raw-materials and energy, using single-step syntheses.
The implementation of such concepts can help to generate more efficient chemical syntheses with higher yields, near-to-zero-waste production for safer and more energy-efficient processes. The experimental space to be explored is immense, expanding from thinking discovering and testing new reactions, to scale up of most successful ideas. In order to be effective it is necessary to develop focused strategies that must address the efficiency issue at various levels, namely:
• atom-efficiency at nano-scale through an “intelligent” activation and reaction of substrates, improving catalyst >>>
Timescale
24 monthsNational and international background
Research in catalysis has the difficult task of finding practical solutions for innovating the chemical industrial production, making sustainable the Chemical Industry. This can be achieved by mastering complexity, either process- or product-complexity, by implementing the principles of “sustainability”. The innovative approach must be integrated at the level of the synthetic methodology, reagents, catalysts, and reaction medium unified in a single strategy mimetic of “enzymatic catalysis”. Such a “new” global approach to problem solving requires the collaboration of various expertise with the combination of efforts and an exchange of information that may reinforce the potential of each partner. The Partners of this Research Project collaborate since a decade within National and International Programmes and have already very successfully run National Projects in the last years with the application at the national level of principles already accepted at the EU level. The objective of this Programme is the “definition of a synthetic strategy that may allow to master the process/product complexity ending with the catalytic synthesis of molecular compounds characterized by multiple functionalities”.The selected target species are:
• Organic carbonates, carbamates, isocyanates, ureas and carboxylates.
• Products for the pharmaceutical industry, namely saturated or unsaturated heterocyclic compounds containing O,N heteroatoms.
• Lactones and lactames >>>
