Contenuto
Ti trovi in: HOME »Programmi, progetti e risultati »I progetti »PRIN - Programmi di ricerca di Rilevante Interesse Nazionale»Programma di ricercaINIZIO_TESTO_DA_INDICIZZARE
RESEARCH PROGRAM
italiano - inglese
Research Units
Similar research programs:
- 1 - Nanoscale self-assembled porphyrin based complexes: properties and technological applications
- 2 - Photo-active Molecular and Polymeric Materials for Optoelectronics and Photonics
- 3 - Supramolecular systems for molecular machines, energy conversion, sensing and catalysis
- 4 - From free molecules to complexes and nanoaggregates: structure, chirality, reactivity and theory
- 5 - Artificial, self-assembled nanoproteins
- 6 - Synthesis, purification and characterization of functionalized carbon nanotubes
- 7 - Stereodynamical factors controlling formation and properties of microaggregates
- 8 - Self-assembling Nanosystems with DNA/RNA-like Addressability
- 9 - AN INTEGRATED APPROACH TO THE SYNTHESIS, CHARACTERIZATION AND FUNCTION OF 5,6-DIHYDROXYINDOLE-DERIVED EUMELANIN BIOPOLYMERS AND THEIR BLENDING WITH CONVENTIONAL POLYMERS AND COMPOSITES
- 10 - Quadruple Helix DNA: Structural and Biological Studies Aimed at the Design of New Anticancer or Antiviral Drugs
Scientific and education field classification
International Patent Classification
- CHEMISTRY; METALLURGY
- ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
- ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)
- GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)
- ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
Geographical classification
- Region: Sicilia
Bibliografia
1) J.-M. Lehn, Supramolecular Chemistry, VCH Weiheim, 19952) U. C. Coskun, T.-C. Wei, S. Vishveshwara, P.M. Goldbart, A. Bezryadin, Science, 2004, 304, 1132.
3) T. Verbiest, S. Van Elshocht, M. Kauranen, L. Hellmans, J. Snauwaert, C. Nuckolls, T. J. Katz, A. Persoons, Sciencs, 1998, 282, 913
4) H. Zhou, L. Baldini, J. Hong, A. J. Wilson, A. D. Hamilton, J. Am. Chem. Soc., 2006, 128, 2421
5) Kondeputi, D. K.; Kaufman, R. J.; Singh, N. Science 1990, 250, 975.
6) Seto, C. T.; Whitesides, G. M. J. Am. Chem. Soc. 1993, 115, 905.
7) De Rossi, U.; Dähne, S.; Meskers, S. C. J.; Dekkers, H. O. J. M. Angew.Chem. Int. Ed. Engl. 1996, 35, 760.
8) Ferrarini, A.; Moro, G. J.; Nordio, P. L. Mol. Phys. 1996, 87, 495.
9) Atwood, J. L.; Mac Gillivray, L. R. Nature 1997, 389, 469.
10) Saurez, M.; Branda, N.; Lehn, J.-M.; De Cian, A.; Fischer, J. Helv. Chim. Acta 1998, 81, 1.
11) Rowan, A.; Nolte, R. J. M. Angew. Chem. Int. Edn. Engl. 1998, 37, 63.
12) Ribò, J. M.; Crusats, J.; Sagues, F.; Claret, J.; Rubires, R. Science 2001, 292, 2063.
13) Stryer, L.; Blout, E. R. J. Am. Chem. Soc. 1961, 83, 1411.
14) Gibbs, E. J.; Tinoco, I.; Maestre, M. F.; Ellinas, P. A.; Pasternack, R. F. Biochem. Biophys. Res. Comm. 1988, 157, 350.
15) Pasternack, R. F.; Giannetto, A.; Pagano, P.; Gibbs, E. J. J. Am. Chem. Soc. 1991, 113, 7799.
16) Purrello, R.; Monsù Scolaro, L.; Bellacchio, E.; Gurrieri, S.; Romeo, A. Inorg. Chem. 1998, 37, 3647.
17) (a) Bellacchio, E.; Lauceri, R.; Monsù Scolaro, L.; Romeo, A.; Purrello, R. J. Am. Chem. Soc. 1998, 120, 12353, (b) Lauceri, R.; Raudino, A.; Monsù Scolaro, L.; Micali, N.; Purrello, R. J. Am. Chem. Soc. 2002, 124, 894.
18) Purrello, R.; Raudino, A.; Monsù Scolaro, L.; Loisi, A.; Bellacchio, E.; Lauceri, R. J. Phys. Chem. 2000, 104, 10900.
19) Yashima, E.; Maeda, K.; Okamoto, Y. Nature 1999, 399, 449-481, (b) Ishikawa, M.; Maeda, K.; Mitsutsuji, Y.; Yashima, E. J. Am. Chem. Soc. 2004, 126, 732.
20) Prins, L. J.; De Jong, F.; Timmermann, P.; Reinhoudt, D. N. Nature 2000, 408, 181.
21) Ziegler, M.; Davis, A. V.; Johnson,D. W., Raymond, K. N., Angew. Chem. Int. Edn. Engl. 2003, 42, 665.
22) Purrello, R. Nature Mat., 2003, 2, 216.
23) J.A.A.E. Elemans, A.E. Rowan, R.J.M. Nolte, J. Mater. Chem. , 2003, 13, 2661.
24) (a) G.C.L. Wong, J.X. Tang, A. Li, Y. Lin, P.A. Janmey, C.R. Safinya, Science 2000, 288, 2035; (b) L.J. Prins, J.J. Verhage, F. de Jong, P. Timmerman, D.N. Reinhoudt, Chem. Eur. J. 2002, 8, 2302; (c) A. Petitjean, L.A. Cuccia, J.-M. Lehn, H. Nierengarten, M. Schumtz, Angew. Chem. Int. Ed. 2002, 41, 1195; (d) K. Velonia, A.E. Rowan, R.J.M. Nolte, J. Am. Chem. Soc. 2002, 124, 4224; (e) L. Brunsveld, J.A.J.M. Vekemans, J.H.K.K. Hirschberg, R.P. Sijbesma, E.W. MeiJer, Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 4977; (f) H. Fenniri, B.-L. Deng, A.E. Ribbe, K. Hallenga, J. Jacob, P. Thiyagarajan, Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 6487.
25) (a) H.A.M. Biemans, A.E. Rowan, A. Verhoeven, P. Vanoppen, L. Latterini, J. Foekema, A.P.H.J. Schenning, E.W. Meijer, F.C. De Schryver, R.J.M. Nolte, J. Am. Chem. Soc. 120, 1998, 11054; (b) C.M. Drain, J.D. Batteas, G.W. Flynn, T. Milic, N. Chi, D.G. Yblon, H. Sommers, Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 6498.
26) K. S. Suslick et al., Nature, 2000, 406, 710
27) T.E.O. Screen, J.R.G. Thorne, R.G. Denning, D.G. Bucknall, H.L. Anderson, J. Am. Chem. Soc., 2002, 124, 9712
28) R.K. Pandey, G. Zheng The porphyrin Handbook, K.M. Kadish, K.M. Smith., R. Guilard, Volume 6, 157
29) J.T. Groves, G. D. Fate, J. Lahiri., J. Am. Chem. Soc., 1994, 116, 5477.
30) R. Lauceri, R. Purrello, S. J. Shetty, M. Graça Vicente, J. Am. Chem. Soc., 2001, 123, 5835.
31) R. Lauceri, S. Gurrieri, E. Bellacchio, A. Contino, L. Monsù Scolaro, A. Romeo, A. Toscano, R. Purrello, Supramolecular Chemistry, 2000, 12, 193.
32) R. Purrello, E. Bellacchio, S. Gurrieri, L. Monsù Scolaro, A. Romeo. Inorg. Chem., 1998, 37, 3647.
33) a) L. Di Costanzo, S. Geremia, L. Randaccio, R. Purrello, R. Lauceri, D. Sciotto, F. G. Gulino, V. Pavone. Angew. Chem. Int. Ed. Engl., 2001, 40, 4245, b) A. Moschetto, R. Lauceri, F. G. Gulino, D. Sciotto, R. Purrello J. Am. Chem. Soc, 2002, 124, 14536-14537, c) F. G. Gulino, R. Lauceri, L. Frish, T. Evan-Salem, Y. Cohen, R. De Zorzi, S. Geremia, L. Randaccio, D. Sciotto, R. Purrello, Chemistry - European J., 2006, 12, 2722.
34) Gutsche, C. D. Calixarenes Revisited In Monographs in Supramolecular Chemistry, Vol. 6 (Ed. Stoddart, J. F.), The Royal Society of Chemistry: Cambridge, 1998; Ikeda, A.; Shinkai, S. Chem. Rev. 1997, 97, 1713; V. Böhmer, V. Angew. Chem. Int. Ed. 1995, 34, 713.
34) Rauf Khan, A.; Forgo, P.; Stine, K. J.; D’Souza, V. T. Chem. Rev. 1998, 98, 1977.
35) Calixarenes 2001, Asfari, Z., Böhmer, V., Harrowfield, J., Vicens, J., Eds.; Kluwer Academic Publishers, Dordrecht, 2001; Mosinger, J.; Tomakova, V.; Nemcova, I.; Zyka, J. Analytical Letters 2001, 34, 1979-2004. Perret, F.; Lazar, A. N.; Coleman, A. W. Chem. Commun. 2006, Advance Article, DOI: 10.1039/b600720c.
36) Y. Rudzevich, V. Rudzevich, C. Moon, I. Schnell, K. Fischer, V. Böhmer J. Amer. Chem. Soc. 2005, 127, 14168.
37) R. K. Castellano, C. Nuckolls, S. H. Eichhorn, M. R. Wood, A. J. Lovinger, J. Rebek, Jr. Angew. Chem. Int. Ed. 1999, 38, 2603.
38) Y. Liu, L. Li, Z. Fan, H. -Y. Zhang, X. Wu, X.-D. Guan, S.-X. Liu Nano Lett. 2002, 2, 257.
39) H. Xu, S. P. Stampp, D. M. Rudkevich Org. Lett. 2003, 5, 4583.
40) D. Garozzo, G. Gattuso, F. H. Kohnke, A. Notti, S. Pappalardo, M. F. Parisi, I. Pisagatti, A. J. P. White, D. J. Williams, Org. Lett. 2003, 5, 4025.
Keywords
NON-COVALENT SYNTHESIS, CHIRALITY, PORPHYRINS, CALIXARENES, CAVITANDS, HIERARCHICAL CONTROLHierarchical self-assembly of multicomponent supramolecular architectures
Università degli Studi di CataniaAbstract
The aim of this research project is the non-covalent synthesis of complex supramolecular systems employing a wide range of different building-blocks (porphirines, phtalocyanines, calixarenes, alkylammonium salts, bipiridine and phenantroline ruthenium complexes). The project focuses on the hierarchical self-assembly of “smart” supramolecular aggregates (chiral memory), resulting from electrostatic interactions between oppositely charged homo- and etero-components, and on the formation of nanostructured architectures (supramolecular polymers) harnessing intermolecular iterative host-guest inclusion events.Some of the specific topics that we would like to investigate concern: the control of stoichiometry, tuning of the degree of aggregation/polymerization in response to chemical stimuli, automated microbatch crystallization, structural characterization of intermediates and final products both in solution and in solid state, separation/segregation of ion pairs, control of the stereochemistry, and induction/amplification of chirality.
Principal Investigator
Roberto Purrello Università degli Studi di CATANIAResearch Objectives
The main goal of this research proposal is the design, synthesis and characterization, both in solution and in the solid state, of homo-molecular (porphyrins:porphyrins and calixarenes:calixarenes) and hetero-molecular (calixarenes:porphyrins) aggregates. The hierarchical self-assembly, control of stoichiometry, tuning of the degree of aggregation/polymerization in response to chemical stimuli, automated microbatch crystallization, ion pair separation/confinement, steric and electronic complementarity, control of the stereochemistry, and induction/amplification of chirality are the specific topics that we will investigate.Collaboration between the Units of Catania, Messina and Trieste stems not only from sharing common research interests, but also from a complementarity of instrumental and synthetic expertise that, owing to a methodological synergy, will allow us to design, prepare, characterize and study novel supramolecular entities. Two different approaches will be employed: classical covalent and non-covalent synthesis. The latter, in fact, is approaching the level of efficiency of traditional covalent-bond chemistry, and it “collaborates” with it for the rational design of suitable building blocks that are able to determine the specific properties of the supramolecular species.
The three Units will collaborate towards the synthesis of:
1) chiral porphyrin complexes;
2) self-assembled calixarene species.
Self-assembled chiral >>>



