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Bibliografia
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Keywords
PHYSICAL CHEMISTRY, COLLOIDS, BIO SURFACTANTS, VESICLES, GELS, SELFORGANIZED SYSTEMS, SUPRAMOLECULAR ASSEMBLIES, SURFACTANT-MACROMOLECULE INTERACTIONS, SYNTHESIS

Biocompatible soft matter systems made of surfactants and macromolecules

Università degli Studi di Roma "La Sapienza"
Abstract
The present program is focused on the investigation of “soft matter systems”, namely water-based self-assembling systems, either sol or gel, made of biocompatible surfactants and macromolecules. Here from, the term macromolecule defines a variety of chemical species, including functionalised polysaccharides, proteins and nucleic acids.
In the program there is a balance between fundamental and applied aspects. The former purposes are directed to getting a deeper insight into structural and other physico-chemical properties, like the transport mechanisms and the kinds of interaction, profitable in order to optimise final formulations characteristics. This will be accomplished by means of the synergetic interpretation of results obtained through various up to date techniques, which encompass a huge range of very different time- and length- scales.
The outcomes are expected to lead to the optimisation of the formulation of systems (micellar aggregates, vesicles, gel, vesicular gels, liquid crystalline or bicontinuous phases) with tailored properties as to dispersion, adsorption, stabilisation and rheology, important for controlled release and cosmetic. To assess the functional synergy associated to the macromolecule-surfactant (P-T) interaction, simple systems, i.e. binary aqueous systems concerning just one macromolecule or surfactant, or at most ternary mixtures, will be studied.
The investigations are embedded in the logic of “eco-sustainable development >>>

Principal Investigator
Nicolae Viorel Pavel Università degli Studi di ROMA "La Sapienza"
Research Objectives
The purpose of this research program deals with the study of supramolecular aqueous systems based on biocompatible surfactants and biocompatible macromolecules both in sol and gel phases.
The study, carried on by five research units (RU) is balanced between the formulation of systems having particular dispersing, stabilising, rheological, and controlled release properties, and their characterization at the fundamental physico-chemical level. In particular, the aim is to deepen the structural study and the interaction and transport mechanisms, required for optimising the properties of formulations. It is our intention to unify the results obtained with different techniques operating on different length and time scales and to correlate them with the rheological properties.

The project is devoted to the study of different complexity systems:
a) Aggregate surfactants in aqueous solution [micelles (M), vesicles (VES)];
b) Sol systems containing water, polymer and surfactant (M or VES);
c) Liquid crystalline or bicontinuous phases (cubosome, hexasome);
d) Polymeric gels of water and polymer;
e) Gel systems made by water, polymer and surfactant (M or VES);
f) Gels in the presence of actives: detailed exam and rationalization of solubilising and transport properties;
g) Surfactant- protein, or DNA, systems in sol and gel phases

The systems under consideration will require a parallel work pointing >>>

Timescale
24 months
National and international background
Systems raising from surfactant and surfactant-macromolecule aggregation belong to soft matter field. They are presently of great interest from both an academic and applicative viewpoint. These systems, presenting a variety of structural and chemical characteristics, are well suited in the building up of materials such as microemulsions, vescicles, gels, liquid crystals, bicontinuos phases. They can also give rise to tridimensional networks organized at different levels: from the molecular to nanometer to millimeter scales.

During the last years, P-T systems found numerous applications in industrial, alimentary, environmental, medical fields, thus raising the scientific interest for the study of their aggregation ability, behavior and structure. Actually literature on this subject is very wide, although we are bound to mention only few papers [1-12] because of the shortness of this document.

In summary, the goal of this project is:
1)Formulation and characterization of new vescicular systems, lyotropic liquid crystals and bicontinuos phases.
2)Formulation of bio-compatible gels made of a polymeric network including surfactants as monomers, micelles or VES
3)Selection of gels for drug delivery presenting good solubilizing and protective ability, rheological and diffusive properties.
4)Study, at micro and macro levels, of P-T and DNA-VES interactions
We will focus on bio-compatible and bio-degradable amphiphilic >>>