RICERCA ITALIANA     

Similar research programs:

• 1 - Supramolecular complexes of sorcin in the generation and regulation of Calcium-dependent cellular functions
• 2 - Role of molecular interactions in the acquisition of the functional structure of model proteins
• 3 - Role of metals – Ubiquitin/Proteasome interaction in the pathogenesis of conformational diseases
• 4 - Molecular features of protein conformational diseases. Role of environmental factors on the structural changes of proteins for the design and the synthesis of agents with antiaggregating, antioxidant, antiglycating and chelating activity and for application in diagnostics.
• 5 - Protein interactomes: unravelling cellular networks in different pathophysiological conditions
• 6 - Regulatory proteins in plants. Bio-molecular analysis of the interaction of 14-3-3 proteins and calmodulin with target proteins
• 7 - The Nedd8 and mono-ubiquitin binding network
• 8 - Molecular analysis of erythropoiesis: Post-genomic and functional approach
• 9 - Supramolecular assemblies. The Dps (DNA-binding proteins from starved cells)- DNA and sorcin - calcium channels systems and their biological function
• 10 - Molecular mechanisms and pathophysiological role of HMGA proteins in hormonal and proliferative signal transmission and transduction.

Scientific and education field classification

• Field: Scienze biologiche
  • BIOCHIMICA
  • BIOLOGIA MOLECOLARE
  • BIOLOGIA APPLICATA

International Patent Classification

• CHEMISTRY; METALLURGY
  • BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF (biocides, pest repellants or attractants, or plant growth regulators, containing micro-organisms, viruses, microbial fungi, enzymes, fermentates or substances produced by or extracted from micro-organisms or animal material A01N63/00; food compositions A21, A23; medicinal preparations A61K; chemical aspects of, or use of materials for, bandages, dressings, absorbent pads or surgical articles A61L; fertilisers C05); PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS (preservation of living parts of humans or animals A01N1/02); MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (micro-biological testing media C12Q)
  • ORGANIC CHEMISTRY (such compounds as the oxides, sulfides, or oxysulfides of carbon, cyanogen, phosgene, hydrocyanic acid or salts thereof C01; products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds C01B33/44; macromolecular compounds C08; dyes C09; fermentation products C12; fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture C12P; production of organic compounds by electrolysis or electrophoresis C25B3/00, C25B7/00)
    • PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

Geographical classification

• Region: Lombardia

Bibliografia

• Andrei, M.E., Burger, C., Peral-Rubio, M.J., Battaglioli, E. et al. CoREST: a functional corepressor required for regulation of neural-specific gene expression. (1999) Proc. Natl. Acad. Sci. USA 96, 9873-9878.
• Ballas, N., Battaglioli, E., et al. (2001) Regulation of neuronal traits by a novel transcriptional complex. Neuron 31, 353-365.
• Bannister J., Schneider, R., Kouzarides, T. (2002) Histone methylation: dynamic or static? Cell 109, 801-806.
• Bannister, A.J., Kouzarides, T. (2005) Reversing histone methylation. Nature 436, 1103-1106.
• Battaglioli, E., Andres, M.E., Rose, D.W., et al. (2002) REST repression of neuronal genes requires components of the hSWI.SNF complex. J. Biol. Chem. 277, 41038-41045.
• Biel, M., Wascholowski, V., Giannis, A. (2005) Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes. Angew. Chem. Int. Ed. 44, 3186-3216.
• Binda, C., Li, M., Hubálek, F., Restelli, N., Edmondson, D.E., Mattevi, A. (2003) New insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high resolution crystal structures. Proc. Natl. Acad. Sci. USA 100, 9750-9755.
• Binda, C., Hubálek, F., Herzig, Y., Sterling, J. Edmondson, D.E., Mattevi, A. (2005) Binding of Rasagiline-related Inhibitors to Human Monoamine Oxidases: A Kinetic and Crystallographic Analysis. J. Medicinal Chemistry 48, 8148-8154.
• Boggon, T.J., et al. (1999) Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286, 2119-2125.
• Bonazzi, M., et al. (2005) CtBP3/BARS drives membrane fission at dynamin-independent trafficking pathways. Nat. Cell Biol. 7, 570-580.
• Bruce, A.W. et al. (2004) Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc. Natl. Acad. Sci. USA 101, 10458-10463.
• Chinnadurai, G. (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell 9, 213-224.
• Chinnadurai, G. (2003) CtBP family proteins: more than transcriptional corepressors. Bioessays 25, 9-12.
• Coleman D.L., Eicher E.M. (1990) Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J. Hered. 8, 424-427.
• Fjeld, C.C., Birdsong, W.T., Goodman, R.H. (2003) Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor. Proc. Natl. Acad. Sci. USA 100, 9202-9207.
• Forneris, F., Binda, C., Vanoni, M.A., Mattevi, A., Battaglioli, E., (2005a). Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett. 579, 2203 – 2207.
• Forneris, F., Binda, C., Vanoni, M.A., Battaglioli. E., Mattevi, A. (2005b). Human histone demethylase LSD1 reads the histone code. J. Biol. Chem. 280, 41360-41365
• Grunstein, M. (1997) Histone acetylation in chromatin structure and transcription. Nature 389, 342-352.
• Gu, S., et al. (1998) Tubby-like protein-1 mutations in autosomal recessive retinitis pigmentosa. Lancet 351, 1103-1104.
• Hagstrom, S.A., et al. (1998) Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with retinitis pigmentosa. Nat. Genet. 18, 174-176.
• Hidalgo Carcedo, C., et al. (2004) Golgi fragmentation during mitosis requires the membrane fissioning protein CtBP3/BARS. Science 305, 93-96.
• Humphrey, G.W., et al. (2001) Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J. Biol. Chem. 276, 6817-6824.
• Ikeda, A., et al.(2001) Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum. Mol. Genet. 10, 1325-1334.
• Inche, A.G., La Thangue, N.B. (2006) Chromatin control and cancer-drug discovery: realizing the promise. Drug Discov. Today 11, 97-109.
• Ikeda A., Nishina P.M., Naggert J.K. (2002) The tubby-like proteins, a family with roles in neuronal development and function. J. Cell Sci. 115, 9-14.
• Jenuwein T., Allis, C.D. (2001) Translating the histone code. Science 293, 1074-1080.
• Kagey, M.H., Melhuish, T.A., Wotton, D. (2003) The polycomb protein Pc2 is a SUMO E3. Cell 113, 127-137.
• Kim, S., Benoiton, L., Paik, W.K. (1964). ?-Alkyllysinase. Purification and properties of the enzyme. J. Biol. Chem. 239, 3790-3796.
• Kumar, V., et al. (2002) Transcription corepressor CtBP is a NAD+-regulated dehydrogenase. Mol. Cell 10, 857-869.
• Lin, X., et al. (2003) Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell 11, 1389-1396.
• Lunyak, V.V., et al. (2002) Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science 29, 1747-1752.
• Massey, V. (1994) Activation of molecular oxygen by flavins and flavoproteins. J. Biol. Chem. 269, 22459-22462.
• Mattevi, A. (2006) To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes. Trends Biochem. Sci., in press.
• Metzger, E., et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437, 436-439.
• Nardini, M., Spanò, S., Cericola, C., Pesce, A., Massaro, A., Millo, E., Luini, A., Corda, D., Bolognesi, M. (2003) CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J. 22, 3122-3130.
• Nardini, M., Svergun, D., Konarev, P.V., Spanò, S., Fasano, M., Bracco, C., Pesce, A., Donadini, A., Cericola, C., Secundo, F., Luini, A., Corda, D., Bolognesi, M. The C-terminal domain of the transcritional co-repressor CtBP is intrinsically disordered. (2006) Protein Sci., in press.
• Santagata, S., et al. (2001) G-protein signaling through tubby proteins. Science 15, 2041-2050.
• Schaeper, U., et al. (1995) Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92, 10467-10471.
• Shi, Y., et al. (2003) Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422, 735-738.
• Shi, Y., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-953.
• Shi, Y.J., et al. (2005) Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 19, 857-864.
• Spotswood, H.T., Turner, B.M. (2002) An increasingly complex code. J. Clin. Invest. 110, 577-582.
• Shiri-Sverdlov, R., et al. (2006) Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes 55, 385-389.
• Svergun, D.I., Koch, M.H.J. (2002) Advances in structure analysis using small-angle scattering in solution. Curr. Opin. Struct. Biol. 12, 654-660.
• Turner, J., and Crossley, M. (2001) The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays 23, 683-690.
• Weigert, R., et al. (1999) CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid. Nature 402, 429-433.
• Yoo, C.B., Jones, P.A. (2006) Epigenetic therapy of cancer: past, present and future. Nature Rev. Drug Discovery 37, 37-50.
• Zhang, Q., Piston, D.W., Goodman, R.H. (2002) Regulation of corepressor function by nuclear NADH. Science 295, 1895-1897.
• Zhang, Q., et al. (2003) Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115, 177-186.
• Zhang, Q., Nottke, A., Goodman, R.H. (2005) Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc. Natl. Acad. Sci. USA 102, 2802-2807.

Keywords

TRANSCRIPTION REGULATION, CHROMATIN REMODELING, HISTONES, PROTEIN COMPLEXES, STRUCTURAL BIOLOGY, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, C-TERMINAL BINDING PROTEIN, DEVELOPMENT, TUMORIGENESIS